The combination of DNA bisulfite treatment with high-throughput sequencing technologies
has enabled investigation of genome-wide DNA methylation at near base pair level …

Human leukemias are liquid malignancies characterized by diffuse infiltration of the bone
marrow by transformed hematopoietic progenitors. The accessibility of tumor cells obtained …

The discovery of cancer-associated alterations has primarily focused on genetic variants.
Nonetheless, altered epigenomes contribute to deregulate transcription and promote …

Cancer chronotherapy, treatment at specific times during circadian rhythms, endeavors to
optimize anti-tumor effects and to lower toxicity. However, comprehensive characterization of …

Understanding the relative contributions of genetic and epigenetic abnormalities to acute
myeloid leukemia (AML) should assist integrated design of targeted therapies. In this study …

There is a growing body of evidence supporting that cancer cells share many similarities
with embryonic stem cells (ESCs). For example, aggressive cancers and ESCs share a …

Targeted therapies against the BCR-ABL1 kinase have revolutionized treatment of chronic
phase (CP) chronic myeloid leukemia (CML). In contrast, management of blast crisis (BC) …

Although tumorigenesis has been accepted as an evolutionary process (,), many forces may
operate differently in cancers than in organisms, as they evolve at vastly different time …

During the last years, several strategies have been made to obtain mature erythrocytes or
red blood cells (RBC) from the bone marrow or umbilical cord blood (UCB). However, UCB …

Hematological malignancy is a disease arisen by complicate reasons that seriously
endangers human health. The research on its pathogenesis and therapies depends on the …