Periodontitis and osteoporosis are prevalent inflammation‐associated skeletal disorders that
pose significant public health challenges to our aging population. Both periodontitis and …

Cellular senescence is a state of terminal growth arrest associated with the upregulation of
different cell cycle inhibitors, mainly p16 and p21, structural and metabolic alterations …

Metformin is one of the most widely prescribed hypoglycemic drugs and has the potential to
treat many diseases. More and more evidence shows that metformin can regulate the …

The aging process is a complex biological phenomenon that results in the gradual decline of
physiological function and an increased risk of age-related diseases. While aging is a …

The inflammasome is a protein complex composed of a variety of proteins in cells and which
participates in the innate immune response of the body. It can be activated by upstream …

Aim Pyroptosis and inflamm‐aging have been newly identified to be involved in diabetic
periodontitis. This study aimed to elucidate whether macrophage pyroptosis plays a role in …

The senescence-associated secretory phenotype (SASP), which accumulates over the
course of normal aging and in age-related diseases, is a crucial driver of chronic …

Periodontitis is a disease of ageing or inflammaging, and is comorbid with other more
severe age-related chronic diseases. With advanced age comes an increase in …

Accelerated cellular senescence may be a crucial process for periodontitis progression
because it integrates the damaging effects of major periodontitis risk factors. Cellular …

As the aging population grows, chronic age-related bone degenerative diseases become
more prevalent and severe. One such disease, periodontitis (PD), rises to 70.1% prevalence …