Interleukin-6 as a therapeutic target
JF Rossi, ZY Lu, M Jourdan, B Klein - Clinical Cancer Research, 2015 - AACR
Human IL6 is a cytokine produced by many cell types that has pleiotropic effects. In
agreement, anti-IL6 therapy reduces inflammation, hepatic acute phase proteins, and …
agreement, anti-IL6 therapy reduces inflammation, hepatic acute phase proteins, and …
[HTML][HTML] The role of marrow microenvironment in the growth and development of malignant plasma cells in multiple myeloma
N Giannakoulas, I Ntanasis-Stathopoulos… - International Journal of …, 2021 - mdpi.com
The development and effectiveness of novel therapies in multiple myeloma have been
established in large clinical trials. However, multiple myeloma remains an incurable …
established in large clinical trials. However, multiple myeloma remains an incurable …
APRIL and BCMA promote human multiple myeloma growth and immunosuppression in the bone marrow microenvironment
YT Tai, C Acharya, G An, M Moschetta… - Blood, The Journal …, 2016 - ashpublications.org
Here we show that overexpression or activation of B-cell maturation antigen (BCMA) by its
ligand, a proliferation-inducing ligand (APRIL), promotes human multiple myeloma (MM) …
ligand, a proliferation-inducing ligand (APRIL), promotes human multiple myeloma (MM) …
Monoclonal gammopathy of undetermined significance
TH Mouhieddine, LD Weeks… - Blood, The Journal of …, 2019 - ashpublications.org
Monoclonal gammopathy of undetermined significance (MGUS) is a premalignant plasma
cell dyscrasia that consistently precedes multiple myeloma (MM) with a 1% risk of …
cell dyscrasia that consistently precedes multiple myeloma (MM) with a 1% risk of …
A phase 2, randomized, double‐blind, placebo‐controlled study of siltuximab (anti‐IL‐6 mAb) and bortezomib versus bortezomib alone in patients with relapsed or …
RZ Orlowski, L Gercheva, C Williams… - American journal of …, 2015 - Wiley Online Library
We compared the safety and efficacy of siltuximab (S), an anti‐interleukin‐6 chimeric
monoclonal antibody, plus bortezomib (B) with placebo (plc)+ B in patients with …
monoclonal antibody, plus bortezomib (B) with placebo (plc)+ B in patients with …
Mesenchymal stromal cell senescence in haematological malignancies
N Plakhova, V Panagopoulos, K Vandyke… - Cancer and Metastasis …, 2023 - Springer
Acute myeloid leukaemia (AML), chronic lymphocytic leukaemia (CLL), and multiple
myeloma (MM) are age-related haematological malignancies with defined precursor states …
myeloma (MM) are age-related haematological malignancies with defined precursor states …
IL-6 supports the generation of human long-lived plasma cells in combination with either APRIL or stromal cell-soluble factors
M Jourdan, M Cren, N Robert, K Bolloré, T Fest… - Leukemia, 2014 - nature.com
The recent understanding of plasma cell (PC) biology has been obtained mainly from
murine models. The current concept is that plasmablasts home to the BM and further …
murine models. The current concept is that plasmablasts home to the BM and further …
Alterations in the transcriptional programs of myeloma cells and the microenvironment during extramedullary progression affect proliferation and immune evasion
D Ryu, SJ Kim, Y Hong, A Jo, N Kim, HJ Kim… - Clinical Cancer …, 2020 - AACR
Purpose: In multiple myeloma, extramedullary progression is associated with treatment
resistance and a high mortality rate. To understand the molecular mechanisms controlling …
resistance and a high mortality rate. To understand the molecular mechanisms controlling …
[HTML][HTML] NSD2 overexpression drives clustered chromatin and transcriptional changes in a subset of insulated domains
P Lhoumaud, S Badri, J Rodriguez-Hernaez… - Nature …, 2019 - nature.com
CTCF and cohesin play a key role in organizing chromatin into topologically associating
domain (TAD) structures. Disruption of a single CTCF binding site is sufficient to change …
domain (TAD) structures. Disruption of a single CTCF binding site is sufficient to change …
Pathogenic long-lived plasma cells and their survival niches in autoimmunity, malignancy, and allergy
Long-lived plasma cells survive in a protected microenvironment for years or even a lifetime
and provide humoral memory by establishing persistent Ab titers. Long-lived autoreactive …
and provide humoral memory by establishing persistent Ab titers. Long-lived autoreactive …