Migratory engineering of T cells for cancer therapy
Adoptive cell therapy (ACT) and chimeric antigen receptor (CAR) T cell therapy in particular
represents an adaptive, yet versatile strategy for cancer treatment. Convincing results in the …
represents an adaptive, yet versatile strategy for cancer treatment. Convincing results in the …
Multiomics insights on the onset, progression, and metastatic evolution of breast cancer
Breast cancer is the most common malignant neoplasm in women. Despite progress to date,
700,000 women worldwide died of this disease in 2020. Apparently, the prognostic markers …
700,000 women worldwide died of this disease in 2020. Apparently, the prognostic markers …
Exploration of immune response mechanisms in cadmium and copper co-exposed juvenile golden cuttlefish (Sepia esculenta) based on transcriptome profiling
X Bao, W Wang, X Chen, Y Feng, X Xu, G Sun… - Frontiers in …, 2022 - frontiersin.org
Sepia esculenta is a popular economic cephalopod with high yield, delicious meat, and rich
nutrition. With the rapid development of heavy industry and medical industry, a large amount …
nutrition. With the rapid development of heavy industry and medical industry, a large amount …
Expression of NOTCH1, NOTCH4, HLA-DMA and HLA-DRA is synergistically associated with T cell exclusion, immune checkpoint blockade efficacy and …
D Liu, P Hofman - Cellular Oncology, 2022 - Springer
Purpose Reliable biomarkers to predict the outcome and treatment response of estrogen
receptor (ER)-negative breast cancer (BC) are urgently needed. Since immune-related …
receptor (ER)-negative breast cancer (BC) are urgently needed. Since immune-related …
Cancer immune exclusion: breaking the barricade for a successful immunotherapy
S Bruni, MF Mercogliano, FL Mauro… - Frontiers in …, 2023 - frontiersin.org
Immunotherapy has changed the course of cancer treatment. The initial steps were made
through tumor-specific antibodies that guided the setup of an antitumor immune response. A …
through tumor-specific antibodies that guided the setup of an antitumor immune response. A …
Adrenocortical Carcinoma Steroid Profiles: In Silico Pan-Cancer Analysis of TCGA Data Uncovers Immunotherapy Targets for Potential Improved Outcomes
JCD Muzzi, JM Magno, MA Cardoso… - Frontiers in …, 2021 - frontiersin.org
Despite progress in understanding the biology of adrenocortical carcinoma (ACC), treatment
options have not dramatically changed in the last three decades, nor have we learned how …
options have not dramatically changed in the last three decades, nor have we learned how …
Integrative analysis constructs an extracellular matrix-associated gene signature for the prediction of survival and tumor immunity in lung adenocarcinoma
L Xiao, Q Li, Y Huang, Z Fan, W Qin, B Liu… - Frontiers in Cell and …, 2022 - frontiersin.org
Background: Lung adenocarcinoma (LUAD) accounts for the majority of lung cancers, and
the survival of patients with advanced LUAD is poor. The extracellular matrix (ECM) is a …
the survival of patients with advanced LUAD is poor. The extracellular matrix (ECM) is a …
m5C regulator‐mediated methylation modification patterns and tumor microenvironment infiltration characteristics in acute myeloid leukemia
Q Wen, SJ Wang, L Hong, S Shen, Y He… - Immunity …, 2024 - Wiley Online Library
Background Recently, many studies have been conducted to examine immune response
modification at epigenetic level, but the candidate effect of RNA 5‐methylcytosine (m5C) …
modification at epigenetic level, but the candidate effect of RNA 5‐methylcytosine (m5C) …
Perioperative corticosteroid treatment impairs tumor-infiltrating dendritic cells in patients with newly diagnosed adult-type diffuse gliomas
C Carenza, S Franzese, A Castagna, S Terzoli… - Frontiers in …, 2023 - frontiersin.org
Introduction Adult-type diffuse gliomas are malignant primary brain tumors characterized by
very poor prognosis. Dendritic cells (DCs) are key in priming antitumor effector functions in …
very poor prognosis. Dendritic cells (DCs) are key in priming antitumor effector functions in …
Identification of hub genes and biological mechanisms associated with non-alcoholic fatty liver disease and triple-negative breast cancer
J Zhu, N Min, W Gong, Y Chen, X Li - Life, 2023 - mdpi.com
The relationship between non-alcoholic fatty liver disease (NAFLD) and triple-negative
breast cancer (TNBC) has been widely recognized, but the underlying mechanisms are still …
breast cancer (TNBC) has been widely recognized, but the underlying mechanisms are still …