An update on cardioprotection: a review of the latest adjunctive therapies to limit myocardial infarction size in clinical trials

PZ Gerczuk, RA Kloner - Journal of the American College of Cardiology, 2012 - jacc.org
Acute myocardial infarction (AMI) with subsequent left ventricular dysfunction and heart
failure continues to be a major cause of morbidity and mortality in the Western world. Rapid …

Nitric oxide mechanisms of nebivolol

A Maffei, G Lembo - Therapeutic advances in cardiovascular …, 2009 - journals.sagepub.com
β-blockers are among the most widely used drugs in the prevention and treatment of
cardiovascular disease, although they are associated with increased peripheral resistance …

[HTML][HTML] Roles of the nitric oxide signaling pathway in cardiac ischemic preconditioning against myocardial ischemia-reperfusion injury

P Weerateerangkul, S Chattipakorn… - … medical journal of …, 2011 - ncbi.nlm.nih.gov
Nitric oxide (NO), a vasoactive gas that can freely diffuse into the cell, has many
physiological effects in various cell types. Since 1986, numerous studies of ischemic …

Nebivolol ameliorates cisplatin‐induced nephrotoxicity in rats

MA Morsy, GH Heeba - Basic & clinical pharmacology & …, 2016 - Wiley Online Library
Abstract Treatment with cisplatin is associated with dose‐limiting side effects, mainly
nephrotoxicity. On the other hand, nebivolol, a β1‐adrenoceptor antagonist, exhibits …

[PDF][PDF] Protective effect of nebivolol on doxorubicin-induced cardiotoxicity in rats

EA Mohamed, HH Kassem - Archives of Medical Science, 2018 - termedia.pl
Results The doxorubicin-treated group showed marked myocyte distortion and
fragmentation, congestion and cytoplasmic lysis in most fibers. These changes were less …

[HTML][HTML] Nebivolol ameliorates sepsis-evoked kidney dysfunction by targeting oxidative stress and TGF-β/Smad/p53 pathway

RT Sabra, AA Bekhit, NT Sabra, NA Abd El-Moeze… - Scientific Reports, 2024 - nature.com
Sepsis is a potential fetal organ destruction brought on through an overzealous immunologic
reaction to infection, causing severe inflammation, septic shock, and damage to different …

Protective effects of nebivolol on ovarian ischemia–reperfusion injury in rat

S Colak, B Gurlek, A Topcu, L Tumkaya… - Journal of Obstetrics …, 2020 - Wiley Online Library
Aim Ovarian torsion is a common gynecological emergency of reproductive ages, occurring
at rates of 2.7–7.4%. This study aimed to evaluate the antioxidant effects of Nebivolol (NEB) …

[HTML][HTML] Nebivolol: vasodilator properties and evidence for relevance in treatment of cardiovascular disease

JG Howlett - Canadian Journal of Cardiology, 2014 - Elsevier
Abstract β-adrenergic blocking agents, a pharmacologically diverse class of cardiovascular
medications, are recommended as first-line treatment for patients with hypertension and …

The anti-oxidant and anti-apoptotic effects of nebivolol and zofenopril in a model of cerebral ischemia/reperfusion in rats

E Uzar, A Acar, O Evliyaoğlu, U Fırat, K Kamasak… - Progress in Neuro …, 2012 - Elsevier
The aim of this experiment was to investigate whether nebivolol and zofenopril have
protective effects against oxidative damage and apoptosis induced by cerebral …

Nebivolol protects against cyclophosphamide‐induced nephrotoxicity through modulation of oxidative stress, inflammation, and apoptosis

H Wanas, M El‐Shabrawy, A Mishriki… - Clinical and …, 2021 - Wiley Online Library
The usefulness of cyclophosphamide (CP) in the treatment of multiple human malignancies
and immunological diseases is hindered by the danger of developing nephrotoxicity. The …