Programmed genome rearrangements in ciliates

I Rzeszutek, XX Maurer-Alcalá, M Nowacki - Cellular and Molecular Life …, 2020 - Springer
Ciliates are a highly divergent group of unicellular eukaryotes with separate somatic and
germline genomes found in distinct dimorphic nuclei. This characteristic feature is tightly …

Programmed Rearrangement in Ciliates: Paramecium

M Betermier, S Duharcourt - Mobile DNA III, 2015 - Wiley Online Library
Ciliates belong to a monophyletic group of unicellular eukaryotes within the Alveolate
branch (1). The species that have been used as model organisms are free‐living organisms …

Structure of the germline genome of Tetrahymena thermophila and relationship to the massively rearranged somatic genome

EP Hamilton, A Kapusta, PE Huvos, SL Bidwell, N Zafar… - elife, 2016 - elifesciences.org
The germline genome of the binucleated ciliate Tetrahymena thermophila undergoes
programmed chromosome breakage and massive DNA elimination to generate the somatic …

Genome-defence small RNAs exapted for epigenetic mating-type inheritance

DP Singh, B Saudemont, G Guglielmi, O Arnaiz… - Nature, 2014 - nature.com
In the ciliate Paramecium, transposable elements and their single-copy remnants are
deleted during the development of somatic macronuclei from germline micronuclei, at each …

The compact macronuclear genome of the ciliate Halteria grandinella: a transcriptome-like genome with 23,000 nanochromosomes

W Zheng, C Wang, M Lynch, S Gao - MBio, 2021 - Am Soc Microbiol
How to achieve protein diversity by genome and transcriptome processing is essential for
organismal complexity and adaptation. The present work identifies that the macronuclear …

Genome-wide analysis of genetic and epigenetic control of programmed DNA deletion

EC Swart, CD Wilkes, PY Sandoval… - Nucleic Acids …, 2014 - academic.oup.com
During the development of the somatic genome from the Paramecium germline genome the
bulk of the copies of∼ 45 000 unique, internal eliminated sequences (IESs) are deleted. IES …

Ciliate research: From myth to trendsetting science

H Plattner - Journal of Eukaryotic Microbiology, 2022 - Wiley Online Library
This special issue of the Journal of Eukaryotic Microbiology (JEM) summarizes
achievements obtained by generations of researchers with ciliates in widely different …

Environmentally induced plasticity of programmed DNA elimination boosts somatic variability in Paramecium tetraurelia

V Vitali, R Hagen, F Catania - Genome Research, 2019 - genome.cshlp.org
Can ecological changes impact somatic genome development? Efforts to resolve this
question could reveal a direct link between environmental changes and somatic variability …

One Cell, Two Gears: Extensive Somatic Genome Plasticity Accompanies High Germline Genome Stability in Paramecium

F Catania, R Rothering, V Vitali - Genome Biology and Evolution, 2021 - academic.oup.com
Mutation accumulation (MA) experiments are conventionally employed to study
spontaneous germline mutations. However, MA experiments can also shed light on somatic …

Cross-Generational Effects and Non-random Developmental Response to Temperature Variation in Paramecium

R Hagen, V Vitali, F Catania - Frontiers in Cell and Developmental …, 2020 - frontiersin.org
Unicellular organisms such as ciliates are largely neglected in research on adaptive
developmental plasticity, although their nuclear dualism offers ideal circumstances to study …