Iron fulfils a central role in many essential biochemical processes in human physiology; thus,
proper processing of iron is crucial. Although iron metabolism is subject to relatively strict …

While mesenchymal stem cells (MSCs)-based therapy appears to be promising, there are
concerns regarding possible side effects related to the unwanted suppression of …

Hepcidin is a key hormone that is involved in the control of iron homeostasis in the body.
Physiologically, hepcidin is controlled by iron stores, inflammation, hypoxia, and …

Hepcidin is central to regulation of iron metabolism. Its effect on a cellular level involves
binding ferroportin, the main iron export protein, resulting in its internalization and …

Hepcidin is a key hormonal regulator of systemic iron homeostasis and its expression is
induced by iron or inflammatory stimuli. Genetic defects in iron signaling to hepcidin lead to …

Iron is required for most forms of organisms, and it is the most essential element for the
functions of many iron-containing proteins involved in oxygen transport, cellular respiration …

Hepcidin, the liver-produced peptide hormone, is a principal regulator of iron homeostasis.
Abnormal hepcidin production has emerged as a causative factor in several common iron …

The discovery of hepcidin clarified the basic mechanism of the control of systemic iron
homeostasis. Hepcidin is mainly produced by the liver as a propeptide and processed by …

The iron regulatory hormone hepcidin limits iron fluxes to the bloodstream by promoting
degradation of the iron exporter ferroportin in target cells. Hepcidin insufficiency causes …

Iron is an essential metal for cell survival that is regulated by the peptide hormone hepcidin.
However, its influence on certain diseases is directly related to iron metabolism or …