Does current scientific and clinical evidence support the use of phosphodiesterase type 5 inhibitors for the treatment of premature ejaculation? A systematic review …

AD Asimakopoulos, R Miano, EF Agrò… - The journal of sexual …, 2012 - academic.oup.com
Introduction Premature ejaculation (PE) is a highly prevalent and complex syndrome that
remains poorly defined and inadequately characterized. Pharmacotherapy represents the …

Current and emerging therapies in premature ejaculation: Where we are coming from, where we are going

C Martin, H Nolen, J Podolnick… - International Journal of …, 2017 - Wiley Online Library
Premature ejaculation is the most common form of sexual dysfunction among men. The
pathophysiology of premature ejaculation appears to be multifactorial, implicating the need …

The controversial role of phosphodiesterase type 5 inhibitors in the treatment of premature ejaculation

EA Jannini, C McMahon, J Chen… - The Journal of …, 2011 - academic.oup.com
Introduction It is controversial whether or not the most frequent male sexual dysfunctions,
premature ejaculation (PE) and erectile dysfunction (ED), share pathogenetic mechanisms …

Efficacy of PDE5Is and SSRIs in men with premature ejaculation: a new systematic review and five meta-analyses

Y Sun, L Yang, Y Bao, Z Liu, L Liu, Q Wei - World Journal of Urology, 2017 - Springer
Purpose To clarify the efficacy of phosphodiesterase-5 inhibitors (PDE5Is) and selective
serotonin reuptake inhibitors (SSRIs) in men with premature ejaculation (PE). Methods We …

The effects of three phosphodiesterase type 5 inhibitors on ejaculation latency time in lifelong premature ejaculators: a double‐blind laboratory setting study

A Gökçe, F Halis, A Demirtas… - BJU international, 2011 - Wiley Online Library
Study Type–Therapy (RCT) Level of Evidence 1b What's known on the subject? and What
does the study add? Several authors have reported their experience with PDE5 inhibitors …

Pharmacotherapy of premature ejaculation: a systematic review and network meta-analysis

Z Jian, X Wei, D Ye, H Li, K Wang - International urology and nephrology, 2018 - Springer
Purpose The purpose of the study was to conduct a systematic evaluation of the different
general prescribed drugs for premature ejaculation (PE). Methods A systematic literature …

Clinical and preclinical treatment of urologic diseases with phosphodiesterase isoenzymes 5 inhibitors: an update

WH Zhang, XH Zhang - Asian journal of andrology, 2016 - journals.lww.com
Abstract Phosphodiesterase isoenzymes 5 inhibitors (PDE5-Is) are the first-line therapy for
erectile dysfunction (ED). The constant discoveries of nitric oxide (NO)/cyclic guanosine …

Is there a role for phosphodiesterase type-5 inhibitors in the treatment of premature ejaculation?

A Aversa, D Francomano, R Bruzziches… - International journal of …, 2011 - nature.com
Premature ejaculation (PE) is considered to be the most common male sexual dysfunction.
The realization that PE may co-exist with ED prompted the use of PDE5-i's alone or in …

Clinical and research concerns with vibratory stimulation: A review and pilot study of common stimulation devices

N Prause, V Roberts, M Legarretta… - Sexual and Relationship …, 2012 - Taylor & Francis
The parameters of vibrators used for sexual stimulation in laboratory settings and
therapeutic contexts are usually unknown. The unidentified range of vibrator characteristics …

Phosphodiesterase type 5 inhibitors and premature ejaculation: an overview of systematic reviews/meta-analyses using the AMSTAR 2, ROBIS, and GRADE tools

IA Abdel-Hamid, M Abo-Aly… - Sexual Medicine …, 2023 - academic.oup.com
Introduction The place of phosphodiesterase type 5 inhibitors (PDE5-Is) in treating
premature ejaculation (PE) remains a therapeutic challenge. Objectives (1) To summarize …