Key Points Genetics of Chronic Kidney Disease Genetic causes of chronic kidney disease
(CKD) are not uncommon. Patients with CKD should be referred for genetic consultation and …

Two coding variants of apolipoprotein L1 (APOL1), called G1 and G2, explain much of the
excess risk of kidney disease in African Americans. While various cytotoxic phenotypes have …

African Americans have a significantly higher risk of developing chronic kidney disease,
especially focal segmental glomerulosclerosis-, than European Americans. Two coding …

Abstract Purpose of Review Elevated blood pressure is the leading modifiable risk factor for
cardiovascular morbidity and mortality in the US. Older individuals, Black adults, and those …

Chronic kidney disease (CKD) is a major healthcare challenge, affecting> 800 million
people worldwide. Implications for population health result from the strong associations of …

BACKGROUND. Two coding alleles within the APOL1 gene, G1 and G2, found almost
exclusively in individuals genetically similar to West African populations, contribute …

Focal segmental glomerulosclerosis (FSGS), a pattern of injury seen in some patients with
nephrotic syndrome, is a leading cause of chronic kidney disease (CKD), especially in …

Notwithstanding remaining controversies and uncertainties, promising genomically precise
therapies targeted at APOL1 mRNA using antisense oligonucleotides (ASO), inhibitors of …

The discovery of the chromosome 22 locus associated with progressive ESKD and FSGS
has paved the road to our understanding of genetic factors contributing to kidney failure …

Apolipoprotein L1 (APOL1) nephropathy results from several podocyte dysfunctions
involving morphological and motility changes, mitochondrial perturbations, inflammatory …