Targeting diffuse midline gliomas: The promise of focused ultrasound-mediated blood-brain barrier opening

PJ Martinez, AL Green, MA Borden - Journal of Controlled Release, 2024 - Elsevier
Diffuse midline gliomas (DMGs), including diffuse intrinsic pontine glioma, have among the
highest mortality rates of all childhood cancers, despite recent advancements in cancer …

Liposome-Mediated Anti-Viral Drug Delivery Across Blood–Brain Barrier: Can Lipid Droplet Target Be Game Changers?

S Mondal, S Ghosh - Cellular and Molecular Neurobiology, 2024 - Springer
Lipid droplets (LDs) are subcellular organelles secreted from the endoplasmic reticulum
(ER) that play a major role in lipid homeostasis. Recent research elucidates additional roles …

A multicellular brain spheroid model for studying the mechanisms and bioeffects of ultrasound-enhanced drug penetration beyond the blood‒brain barrier

AN Paranjape, L D'Aiuto, W Zheng, X Chen… - Scientific Reports, 2024 - nature.com
The blood‒brain barrier (BBB) acts as a hindrance to drug therapy reaching the brain. With
an increasing incidence of neurovascular diseases and brain cancer metastases, there is a …

Breaking Barriers in Neuro-Oncology: A Scoping Literature Review on Invasive and Non-Invasive Techniques for Blood–Brain Barrier Disruption

M Pinkiewicz, M Pinkiewicz, J Walecki, A Zaczyński… - Cancers, 2024 - mdpi.com
Simple Summary Advancements in understanding the blood–brain barrier (BBB) and blood–
tumor barrier (BTB) structures emphasize the need to explore functional differences …

Bibliometric and visualized analysis of ultrasound combined with microbubble therapy technology from 2009 to 2023

B Tu, Y Li, W Wen, J Liu - Frontiers in Pharmacology, 2024 - frontiersin.org
Background In recent years, with the rapid advancement of fundamental ultrasonography
research, the application of ultrasound in disease treatment has progressively increased. An …

[HTML][HTML] Effect of Microbubble Size, Composition and Multiple Sonication Points on Sterile Inflammatory Response in Focused Ultrasound-Mediated Blood-Brain …

PJ Martinez, JJ Song, J Castillo, J DeSisto, KH Song… - bioRxiv, 2024 - ncbi.nlm.nih.gov
Blood-brain barrier opening (BBBO) using focused ultrasound (FUS) and microbubbles
(MBs) has emerged as a promising technique for delivering therapeutics to the brain …

Intravital Imaging of Rapid Short-pulse Ultrasound-Induced Blood-Tumor Barrier Opening with Two-photon Microscopy

Y Xu, M Hu, O Zhao, X Chen, S Chen… - 2023 IEEE …, 2023 - ieeexplore.ieee.org
Rapid short-pulse (RaSP) ultrasound with microbubbles is a novel modality for blood-brain
barrier (BBB) opening and intracranial drug delivery, which has less energy and thus …

[引用][C] Anurag N. Paranjape, Leonardo D'Aiuto 3, Wenxiao Zheng 3, 4, Xucai Chen &

FS Villanueva - Scientific Reports, 2024 - europepmc.org
The blood‒brain barrier (BBB) acts as a hindrance to drug therapy reaching the brain. With
an increasing incidence of neurovascular diseases and brain cancer metastases, there is a …