Aging is defined as a progressive time‐related accumulation of changes responsible for or
at least involved in the increased susceptibility to disease and death. The brain seems to be …

Aging is accompanied by many changes in brain and contributes to progressive cognitive
decline. In contrast to pathological changes in brain, normal aging brain changes have …

Importance Mounting evidence suggests that sex differences exist in the pathologic
trajectory of Alzheimer disease. Previous literature shows elevated levels of cerebrospinal …

Clinical studies indicate that Alzheimer's disease (AD) disproportionately affects women in
both disease prevalence and rate of symptom progression, but the mechanisms underlying …

Objective The goal of this study was to examine sex differences in tau distribution across the
brain of older adults, using positron emission tomography (PET), and investigate how these …

Abnormal tau protein impairs mitochondrial function, including transport, dynamics, and
bioenergetics. Mitochondria interact with the endoplasmic reticulum (ER) via mitochondria …

Aging is the major risk factor for neurodegenerative diseases, accelerated by excessive
calorie consumption and sedentary lifestyles. Bioenergetic challenges such as intermittent …

Alzheimer's disease (AD) is a progressive neurodegenerative disease that represents the
most common form of dementia among the elderly. Despite the fact that AD was studied for …

So far, the search for a cure for Alzheimer Disease (AD) has been unsuccessful. The only
approved drugs attenuate some symptoms, but do not halt the progress of this disease …

Estradiol, either from peripheral or central origin, activates multiple molecular
neuroprotective and neuroreparative responses that, being mediated by estrogen receptors …