Many cellular processes require large-scale rearrangements of chromatin structure.
Structural maintenance of chromosomes (SMC) protein complexes are molecular machines …

Immune cell development and activation demand the precise and coordinated control of
transcriptional programmes. Three-dimensional (3D) organization of the genome has …

The DNA double-strand break repair complex Mre11-Rad50-Nbs1 (MRN) detects and
nucleolytically processes DNA ends, activates the ATM kinase, and tethers DNA at break …

Extended loop extrusion across the immunoglobulin heavy-chain (Igh) locus facilitates VH-
DJH recombination following downregulation of the cohesin-release factor Wapl by Pax5 …

Immunoglobulin heavy chain variable region exons are assembled in progenitor-B cells,
from VH, D, and JH gene segments located in separate clusters across the Igh locus. RAG …

Antigen receptor loci are organized into variable (V), diversity (D) and joining (J) gene
segments that rearrange to generate antigen receptor repertoires. Here, we identified an …

In mammals, B cells strictly segregate proliferation from somatic mutation as they develop
within the bone marrow and then mature through germinal centers (GCs) in the periphery …

SHLD1 is part of the Shieldin (SHLD) complex, which acts downstream of 53BP1 to
counteract DNA double-strand break (DSB) end resection and promote DNA repair via non …

During an infection the immune system produces pathogen-specific antibodies. These
antibody repertoires become specific to the history of infections and represent a rich source …

Systemic lupus erythematosus (SLE) is a prime example of how the interplay between
genetic and environmental factors can trigger systemic autoimmunity, particularly in young …