Although more studies are demonstrating that a father's environment can influence child
health and disease, the molecular mechanisms underlying non-genetic inheritance remain …

BACKGROUND It has long been thought that the factors affecting embryo and foetal
development were exclusively maternally derived; hence, if issues regarding fertility and …

Genetic defects of GNAS, the imprinted gene encoding the stimulatory G protein α-subunit,
are responsible for multiple diseases. Abnormal GNAS imprinting causes …

Heterochromatin marks such as H3K9me3 undergo global erasure and re-establishment
after fertilization, and the proper reprogramming of H3K9me3 is essential for early …

As an important epigenetic modification, DNA methylation is involved in many biological
processes such as animal cell differentiation, embryonic development, genomic imprinting …

In mammals, global passive demethylation contributes to epigenetic reprogramming during
early embryonic development. At this stage, the majority of DNA-methyltransferase 1 …

Current chemical testing strategies are limited in their ability to detect non-genotoxic
carcinogens (NGTxC). Epigenetic anomalies develop during carcinogenesis regardless of …

Ubiquitin-like with PHD and RING finger domains 1 (UHRF1) is an epigenetic regulator that
plays critical roles in tumours. However, the DNA methylation alteration patterns driven by …

The changes in epigenetic modifications during early embryonic development significantly
impact mammalian embryonic genome activation (EGA) and are species-conserved to some …

Embryos, originating from fertilized eggs, undergo continuous cell division and
differentiation, accompanied by dramatic changes in transcription, translation, and …