Prions are unprecedented infectious pathogens that cause a group of invariably fatal
neurodegenerative diseases by an entirely novel mechanism. Prion diseases may present …

Prions cause transmissible and genetic neurodegenerative diseases, including scrapie and
bovine spongiform encephalopathy of animals and Creutzfeldt-Jakob and Gerstmann …

The discovery of infectious proteins, denoted prions, was unexpected. After much debate
over the chemical basis of heredity, resolution of this issue began with the discovery that …

PrPc is a host protein anchored to the outer surface of neurons and to a lesser extent of
lymphocytes and other cells. The transmissible agent (prion) responsible for scrapie is …

There are many strains of the agents that cause transmissible spongiform encephalopathies
(TSEs) or 'prion'diseases. These strains are distinguishable by their disease characteristics …

Transmissible spongiform encephalopathies (TSEs) are inevitably lethal neurodegenerative
diseases that affect humans and a large variety of animals. The infectious agent responsible …

Prion diseases are transmissible spongiform encephalopathies (TSEs), attributed to
conformational conversion of the cellular prion protein (PrPC) into an abnormal conformer …

Transgenic (Tg) mice expressing both Syrian hamster (Ha) and mouse (Mo) prion protein
(PrP) genes were used to probe the mechanism of scrapie prion replication. Four Tg lines …

Bovine spongiform encephalopathy (BSE) and human Creutzfeldt-Jakob disease (CJD) are
among the most notable central nervous system degenerative disorders caused by prions …

Byron W. Caughey,*'* Aichun Dong,* Kolari S. Bhat,* Darwin Ernst,* Stanley F. Hayes,* and
Winslow S. Caughey* NIAID, NationalInstitutes of Health, Rocky Mountain Laboratories …