The renin-angiotensin system (RAS) plays an important role in regulating body fluids and
blood pressure. However, inappropriate activation of the RAS contributes to the …

Aryl C-glycosides are an important class of carbohydrate derivatives, with widespread
application in drug development, biochemistry and material sciences. However, their …

Abstract Sodium-glucose cotransporter 2 (SGLT2) inhibitor clinical studies in type 1 diabetes
mellitus (T1DM) have demonstrated reduced HbA1c and lower glucose variability with …

Facile preparation of the α-C-vinyl and-aryl glycosides has been developed via mild Ni-
catalyzed reductive vinylation and arylation of C1-glycosyl halides with vinyl/aryl halides …

New drugs introduced to the market every year represent privileged structures for particular
biological targets. These new chemical entities (NCEs) provide insight into molecular …

The acetal (O-glycoside) bonds of glycans and glycoconjugates are chemically and
biologically vulnerable, and therefore C-glycosides are of interest as more stable analogs …

In this study, we present a cobalt-catalyzed C3-glycosylation of indoles using
unfunctionalized glycals, yielding 3-indolyl-C-deoxyglycosides. These compounds hold …

Preparation of S-aryl thioglycosides from 1-thiosugars via S-arylation was demonstrated
under mild reaction conditions. A wide range of protected and unprotected 1-thiosugars …

A radical-mediated method was reported for diastereoselective synthesis of non-classical
heteroaryl C-glycosides via Minisci-type alkylation of N-heteroarenes with 4-glycosyl-1, 4 …

A rapid and mild protocol for the exhaustive deoxygenation of various aromatic ketones to
corresponding alkanes was described, which was mediated by TiCl4 and used ammonia …