The first report demonstrating that prolonged endurance exercise promotes oxidative stress
in humans was published more than 4 decades ago. Since this discovery, many ensuing …

The progressive increase in lifespan over the past century carries with it some adversity
related to the accompanying burden of debilitating diseases prevalent in the older …

Skeletal muscle aging is associated with a significant loss of skeletal muscle strength and
power (ie, dynapenia), muscle mass and quality of life, a phenomenon known as …

We propose in this review that hormesis, a concept profoundly and systematically addressed
by Mark Mattson, has to be considered a sort of comprehensive “contact point” capable of …

Geroscience offers a counterpoint to the challenged pursuit of curing diseases of aging, by
focusing on slowing the biological aging process for extended healthspan earlier in life …

Reversible and sub-lethal stresses to the mitochondria elicit a program of compensatory
responses that ultimately improve mitochondrial function, a conserved anti-aging …

Cells have the ability to adapt to stressful environments as a part of their evolution. Physical
exercise induces an increase of a demand for energy that must be met by mitochondria as …

Skeletal muscle is a highly adaptable organ, and its amount declines under catabolic
conditions such as critical illness. Aging is accompanied by a gradual loss of muscle …

Mitochondrial health is based on a delicate balance of specific mitochondrial functions (eg
metabolism, signaling, dynamics) that are impaired in neurodegenerative diseases …

Hormesis is any kind of biphasic dose-response when low doses of some agents are
beneficial while higher doses are detrimental. Radiation hormesis is the most thoroughly …