This review article provides a historical perspective on the role of purinergic signalling in the
regulation of various subsets of immune cells from early discoveries to current …

Purinergic signaling plays important roles in control of vascular tone and remodeling. There
is dual control of vascular tone by ATP released as a cotransmitter with noradrenaline from …

Interferon-stimulated genes (ISGs) form the backbone of the innate immune system and are
important for limiting intra-and intercellular viral replication and spread. We conducted a …

Abstract P2Y receptors are G protein‐coupled receptors (GPCRs) that are activated by
adenine and uridine nucleotides and nucleotide sugars. There are eight subtypes of P2Y …

Extracellular ATP and related nucleotides promote a wide range of pathophysiological
responses via activation of cell surface purinergic P2 receptors. Almost every cell type …

P2 receptors that are activated by extracellular nucleotides (eg, ATP, ADP, UTP, UDP, Ap n
A) and P1 receptors activated by adenosine control a diversity of biological processes. The …

The purinergic signalling system, which uses purines and pyrimidines as chemical
transmitters, and purinoceptors as effectors, is deeply rooted in evolution and development …

Inflammation is the most fundamental body reaction to noxious stimuli. No vascularized
tissue, organ or apparatus is free from this response. Several mediators of inflammation …

Introduction Clearance of damaged cells and debris is beneficial for the functional recovery
after ischemic brain injury. However, the specific phagocytic receptor that mediates …

Blood vessels are subjected to mechanical loads of pressure and flow, inducing smooth
muscle circumferential and endothelial shear stresses. The perception and response of …