Environmental insults impair human health around the world. Contaminated air, water, soil,
food, and occupational and household settings expose humans of all ages to a plethora of …

Sarcopenia is a loss of muscle mass and function in the elderly that reduces mobility,
diminishes quality of life, and can lead to fall-related injuries, which require costly …

There is increasing evidence that skin aging is significantly enforced by the accumulation of
senescent dermal fibroblasts. Various stressors damaging macromolecules inside and …

Mice and humans with growth hormone receptor/IGF-1 deficiencies display major reductions
in age-related diseases. Because protein restriction reduces GHR-IGF-1 activity, we …

Obesity is associated with functional limitations in muscle performance and increased
likelihood of developing a functional disability such as mobility, strength, postural and …

Changing demographics make it ever more important to understand the modifiable risk
factors for disability and loss of independence with advancing age. For more than two …

The effects of aging on the immune system are manifest at multiple levels that include
reduced production of B and T cells in bone marrow and thymus and diminished function of …

Mouse models with cell-specific deletion of the estrogen receptor (ER) α, the androgen
receptor (AR) or the receptor activator of nuclear factor κB ligand (RANKL), as well as …

Frailty is the most problematic expression of population ageing. It is a state of vulnerability to
poor resolution of homoeostasis after a stressor event and is a consequence of cumulative …

At high concentrations, free radicals and radical-derived, nonradical reactive species are
hazardous for living organisms and damage all major cellular constituents. At moderate …