Vaginal ring devices capable of providing sustained/controlled release of incorporated
actives are already marketed for steroidal contraception and estrogen replacement therapy …

Vaginal HIV microbicides are topical, self administered products designed to prevent or
significantly reduce transmission of HIV infection in women. The earliest microbicide …

The new generation broadly neutralizing antibody VRC01 against HIV-1 shows great
potential as a topically administered microbicide to prevent sexual transmission. We …

The continued spread of HIV underscores the need to interrupt transmission. One attractive
strategy, in the absence of an effective vaccine, is a topical microbicide, but the need for …

For prevention of HIV infection many currently licensed anti-HIV drugs and new ones in the
pipeline show potential as topically applied microbicides. While macaque models have …

Boron organometallic compounds are mainly known for their great value in organic
synthesis to construct biaryls in Suzuki couplings, for arylations of olefins, for C–S, C–O, and …

The HIV-1 epidemic remains unchecked despite existing technology; vaccines and
microbicides in development may help reverse the epidemic. Reverse transcriptase …

The same populations of women at risk for sexual acquisition of HIVare also at risk for
pregnancy; many of these women use contraception. Combating the spread of HIV is a …

In tissue, mononuclear phagocytes (MNP) are comprised of Langerhans cells, dendritic
cells, macrophages and monocyte-derived cells. They are the first immune cells to …

Several broad-spectrum microbicides, including cellulose sulfate (CS), have passed
conventional preclinical and phase I clinical safety evaluation and yet have failed to protect …