Upon receipt in the dorsal horn (DH) of the spinal cord, nociceptive (pain-signalling)
information from the viscera, skin and other organs is subject to extensive processing by a …

In 1978, we published two reviews on pain control mechanisms in the central nervous
system. One concentrated on brainstem control of spinal nociceptive neurons (Fields & …

The present edition of The Human Central Nervous System differs considerably from its
predecessors. In previous editions, the text was essentially confined to a section dealing …

Sixty-eight convergent dorsal horn neurones have been recorded at the lumbar level in
anaesthetized intact rats. All cells received prominent Aα and C fibre afferents and …

The effect of naloxone on dental postoperative pain was studied to examine the hypothesis
that endorphins mediate placebo analgesia. All patients had extraction of impacted …

Clonidine has proved to be a clinically useful adjunct in clinical anaesthetic practice as well
as in chronic pain therapy because it has both anaesthetic and analgesic‐sparing activity …

The anatomy, physiology, and pharmacology of an intrinsic neural network that monitors and
modulates the activity of pain‐transmitting neurons is reviewed. This system can be …

Chronic pain, whether the result of nerve trauma or persistent inflammation, is a debilitating
condition that exerts a high social cost in terms of productivity, economic impact and quality …

The cloning of the opioid receptors has profoundly affected our understanding of opioid-
receptor expression, regulation and function. This review focuses on the impact that cloning …

Chronic migraine is a disabling neurological disorder that imposes a considerable burden
on individual and socioeconomic outcomes. Chronic migraine is defined as headaches …