A critical question related to the deactivation of mitochondrial metabolism in heart failure is
whether such energy metabolic abnormalities contribute to the pathology of, or are …

Because of their wide range of actions on glucose homeostasis, lipid metabolism and
vascular inflammation, peroxisome proliferator-activated receptors (PPARs) are promising …

There is an overwhelming weight of evidence that certifies cardiac troponin (cTn) as the
preferred, defacto, translational, safety biomarker for myocardial injury in cardiotoxicity. As …

10+ Years of Updates Since First EditionNewcomers to the animal clinical chemistry and
toxicology fields quickly find that the same rules of human medicine do not always apply …

Aims Peroxisome proliferator-activated receptor-α (PPARα) is a nuclear receptor regulating
cardiac metabolism that also has anti-inflammatory properties. Since the activation of …

Introduction 3. Molecular basis of RyR2 redox regulation 3.1. Nitric Oxide Synthases and
RyR2 S-Nitrosylation 3.1. 1. Localization and function of NOS isoforms in cardiac myocytes …

Excessive fatty acid (FA) uptake by cardiac myocytes is often associated with adverse
changes in cardiac function. This is especially evident in diabetic individuals, where …

Key features: Serves as the detailed, authoritative source of the clinical chemistry of the most
commonly used laboratory animals Includes detailed chapters dedicated to descriptions of …

Mitochondria play a fundamental role in the maintenance of normal structure, function, and
survival of tissues. There is considerable evidence for mitochondrial dysfunction in …

Environmental stressors during developmental stages are hypothesized to increase the risk
of developing metabolic diseases such as obesity, type 2 diabetes, hypertension, and …