Intestinal epithelial glycosylation in homeostasis and gut microbiota interactions in IBD

MR Kudelka, SR Stowell, RD Cummings… - Nature reviews …, 2020 - nature.com
Inflammatory bowel disease (IBD) affects 6.8 million people globally. A variety of factors
have been implicated in IBD pathogenesis, including host genetics, immune dysregulation …

[HTML][HTML] The role of neutrophils during intestinal inflammation

BM Fournier, CA Parkos - Mucosal immunology, 2012 - Elsevier
Polymorphonuclear leukocytes or neutrophils play a critical role in the maintenance of
intestinal homeostasis. They have elegant defense mechanisms to eliminate microbes that …

Gut health, stress, and immunity in neonatal dairy calves: the host side of host-pathogen interactions

JS Osorio - Journal of animal science and biotechnology, 2020 - Springer
The cumulative evidence that perinatal events have long-lasting ripple effects through the
life of livestock animals should impact future nutritional and management recommendations …

Collapse of the microbiome, emergence of the pathobiome, and the immunopathology of sepsis

JC Alverdy, MA Krezalek - Critical care medicine, 2017 - journals.lww.com
The definition of sepsis has been recently modified to accommodate emerging knowledge in
the field, while at the same time being recognized as challenging, if not impossible, to …

The role of polymorphonuclear leukocyte trafficking in the perpetuation of inflammation during inflammatory bowel disease

JC Brazil, NA Louis, CA Parkos - Inflammatory bowel diseases, 2013 - academic.oup.com
The inflammatory bowel diseases (IBDs; Crohn's disease, and ulcerative colitis) are
chronically relapsing inflammatory disorders of the intestine and/or colon. The precise …

[HTML][HTML] Finding the sweet spot: glycosylation mediated regulation of intestinal inflammation

JC Brazil, CA Parkos - Mucosal Immunology, 2022 - Elsevier
Glycans are essential cellular components that facilitate a range of critical functions
important for tissue development and mucosal homeostasis. Furthermore, specific …

Regulatory mechanisms of neutrophil migration from the circulation to the airspace

WC Lin, MB Fessler - Cellular and Molecular Life Sciences, 2021 - Springer
The neutrophil, a short-lived effector leukocyte of the innate immune system best known for
its proteases and other degradative cargo, has unique, reciprocal physiological interactions …

Can methicillin-resistant Staphylococcus aureus silently travel from the gut to the wound and cause postoperative infection? Modeling the “Trojan Horse Hypothesis”

MA Krezalek, S Hyoju, A Zaborin, E Okafor… - Annals of …, 2018 - journals.lww.com
Objective: To determine whether intestinal colonization with methicillin-resistant
Staphylococcus aureus (MRSA) can be the source of surgical site infections (SSIs) …

JAM-related proteins in mucosal homeostasis and inflammation

AC Luissint, A Nusrat, CA Parkos - Seminars in immunopathology, 2014 - Springer
Mucosal surfaces are lined by epithelial cells that form a physical barrier protecting the body
against external noxious substances and pathogens. At a molecular level, the mucosal …

Pathobiology of neutrophil–epithelial interactions

JC Brazil, CA Parkos - Immunological reviews, 2016 - Wiley Online Library
Polymorphonuclear neutrophils (PMN s) are innate immune system cells that play an
essential role in eradicating invading pathogens. PMN migration to sites of …