[HTML][HTML] The role of ceramide and sphingosine-1-phosphate in Alzheimer's disease and other neurodegenerative disorders
K Czubowicz, H Jęśko, P Wencel, WJ Lukiw… - Molecular …, 2019 - Springer
Bioactive sphingolipids—ceramide, sphingosine, and their respective 1-phosphates (C1P
and S1P)—are signaling molecules serving as intracellular second messengers. Moreover …
and S1P)—are signaling molecules serving as intracellular second messengers. Moreover …
Role of ceramide/sphingomyelin (SM) balance regulated through “SM cycle” in cancer
M Taniguchi, T Okazaki - Cellular signalling, 2021 - Elsevier
Sphingomyelin synthase (SMS), which comprises of two isozymes, SMS1 and SMS2, is the
only enzyme that generates sphingomyelin (SM) by transferring phosphocholine of …
only enzyme that generates sphingomyelin (SM) by transferring phosphocholine of …
[HTML][HTML] Ceramide/sphingomyelin rheostat regulated by sphingomyelin synthases and chronic diseases in murine models
M Taniguchi, T Okazaki - Journal of Lipid and Atherosclerosis, 2020 - ncbi.nlm.nih.gov
Ceramide and sphingomyelin (SM) are major components of the double membrane-bound
sphingolipids. Ceramide is an essential bioactive lipid involved in numerous cell processes …
sphingolipids. Ceramide is an essential bioactive lipid involved in numerous cell processes …
[HTML][HTML] Lack of sphingomyelin synthase 2 reduces cerebral ischemia/reperfusion injury by inhibiting microglial inflammation in mice
Y Yang, F Hu, G Yang, Q Meng - Experimental and …, 2020 - spandidos-publications.com
Recanalization of blood flow after ischemia can lead to ischemia/reperfusion injury, and
inflammation plays an important role in the mechanisms behind cerebral …
inflammation plays an important role in the mechanisms behind cerebral …
[HTML][HTML] SGMS2 in primary osteoporosis with facial nerve palsy
S Pihlström, S Richardt, K Määttä… - Frontiers in …, 2023 - frontiersin.org
Pathogenic heterozygous variants in SGMS2 cause a rare monogenic form of osteoporosis
known as calvarial doughnut lesions with bone fragility (CDL). The clinical presentations of …
known as calvarial doughnut lesions with bone fragility (CDL). The clinical presentations of …
Disruption of sphingomyelin synthase 2 gene alleviates cognitive impairment in a mouse model of Alzheimer's disease
O Uchiumi, J Zou, S Yamaki, Y Hori, M Ono… - Brain Research, 2024 - Elsevier
The membrane raft accommodates the key enzymes synthesizing amyloid β (Aβ). One of the
two characteristic components of the membrane raft, cholesterol, is well known to promote …
two characteristic components of the membrane raft, cholesterol, is well known to promote …
Remodeling of projections from ventral hippocampus to prefrontal cortex in Alzheimer's mice
F Xu, M Ono, T Ito, O Uchiumi, F Wang… - Journal of …, 2021 - Wiley Online Library
Emotional dysregulation often accompanies cognitive deficits in Alzheimer's disease (AD).
The hippocampus, most notably damaged by AD pathology, is classified into the cognition …
The hippocampus, most notably damaged by AD pathology, is classified into the cognition …
[HTML][HTML] Neurodevelopment and cognitive impairment in parents and progeny of perinatal dietary protein deficiency models
There is an absolute dependence of the concept of development on supply of adequately
balanced nutrients especially during the perinatal age which is critical to development …
balanced nutrients especially during the perinatal age which is critical to development …