Mechanical signalling affects multiple biological processes during development and in adult
organisms, including cell fate transitions, cell migration, morphogenesis and immune …

Genomic instability is a primary cause and fundamental feature of human cancer. However,
all cancer cell genotypes generally translate into several common pathophysiological …

The tumor microenvironment is a dynamic landscape in which the physical and mechanical
properties evolve dramatically throughout cancer progression. These changes are driven by …

Recent rapid progress in the field of mechanobiology has been driven by novel emerging
tools and methodologies and growing interest from different scientific disciplines. Specific …

Human red blood cells (RBC) are highly differentiated cells that have lost all organelles and
most intracellular machineries during their maturation process. RBC are fundamental for the …

Cells constantly encounter mechanical stimuli in their environment, such as dynamic forces
and mechanical features of the extracellular matrix. These mechanical cues are transduced …

Mechanosensitive (MS) ion channels are integral membrane proteins which play a crucial
role in fast signaling during mechanosensory transduction processes in living cells. They are …

Mechanotransduction, the translation of mechanical stimuli into biological signals, is a
crucial mechanism involved in the function of fundamentally all cell types. In many solid …

The mechanically activated Piezo channels, including Piezo1 and Piezo2 in mammals,
function as key mechanotransducers for converting mechanical force into electrochemical …

Endogenous PIEZO1 channels of native endothelium lack the hallmark inactivation often
seen when these channels are overexpressed in cell lines. Because prior work showed that …