The fundamental roles that peptides and proteins play in today's biology makes it almost
indisputable that peptides were key players in the origin of life. Insofar as it is appropriate to …

Building on our ability to design and synthesise molecules and our understanding of the
noncovalent interactions between these molecules, the chemical sciences are currently …

The design of artificial catalysts able to compete with the catalytic proficiency of enzymes is
an intense subject of research. Non-covalent interactions are thought to be involved in …

The origin of life is a fascinating, unresolved problem whose deciphering would have
important scientific, epistemological and social implications. Over time, philosophers and …

The process by which chemistry can give rise to biology remains one of the biggest
mysteries in contemporary science. The de novo synthesis and origin of life both require the …

Self‐replication is a fundamental concept. The idea of an entity that can repeatedly create
more of itself has captured the imagination of many thinkers from von Neumann to …

Modern cells embody metabolic networks containing thousands of elements and form
autocatalytic sets of molecules that produce copies of themselves. How the first self …

The study of complex mixtures of interacting synthetic molecules has historically not
received much attention from chemists, even though research into complexity is well …

A fundamental challenge in synthetic biology is to create molecular circuits that can program
complex cellular functions. Because proteins can bind, cleave, and chemically modify one …

The weak-link approach (WLA) to supramolecular assemblies allows for the design of
multimetallic two-and three-dimensional arrays, host− guest architectures, sensors …