Cellular mechanotransduction in health and diseases: from molecular mechanism to therapeutic targets
Cellular mechanotransduction, a critical regulator of numerous biological processes, is the
conversion from mechanical signals to biochemical signals regarding cell activities and …
conversion from mechanical signals to biochemical signals regarding cell activities and …
Emerging cellular and molecular determinants of idiopathic pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF), the most common form of idiopathic interstitial
pneumonia, is a progressive, irreversible, and typically lethal disease characterized by an …
pneumonia, is a progressive, irreversible, and typically lethal disease characterized by an …
Distribution of ACE2, CD147, CD26, and other SARS‐CoV‐2 associated molecules in tissues and immune cells in health and in asthma, COPD, obesity, hypertension …
U Radzikowska, M Ding, G Tan, D Zhakparov, Y Peng… - Allergy, 2020 - Wiley Online Library
Background Morbidity and mortality from COVID‐19 caused by novel coronavirus SARS‐
CoV‐2 is accelerating worldwide, and novel clinical presentations of COVID‐19 are often …
CoV‐2 is accelerating worldwide, and novel clinical presentations of COVID‐19 are often …
Cellular senescence mediates fibrotic pulmonary disease
MJ Schafer, TA White, K Iijima, AJ Haak… - Nature …, 2017 - nature.com
Idiopathic pulmonary fibrosis (IPF) is a fatal disease characterized by interstitial remodelling,
leading to compromised lung function. Cellular senescence markers are detectable within …
leading to compromised lung function. Cellular senescence markers are detectable within …
Alveolar epithelial type II cells as drivers of lung fibrosis in idiopathic pulmonary fibrosis
Alveolar epithelial type II cells (AT2) are a heterogeneous population that have critical
secretory and regenerative roles in the alveolus to maintain lung homeostasis. However …
secretory and regenerative roles in the alveolus to maintain lung homeostasis. However …
Extracellular matrix as a driver of progressive fibrosis
J Herrera, CA Henke… - The Journal of clinical …, 2018 - Am Soc Clin Investig
The extracellular matrix (ECM) is dynamically tuned to optimize physiological function. Its
major properties, including composition and mechanics, profoundly influence cell biology …
major properties, including composition and mechanics, profoundly influence cell biology …
[HTML][HTML] Single-cell deconvolution of fibroblast heterogeneity in mouse pulmonary fibrosis
Fibroblast heterogeneity has long been recognized in mouse and human lungs,
homeostasis, and disease states. However, there is no common consensus on fibroblast …
homeostasis, and disease states. However, there is no common consensus on fibroblast …
Senescence of alveolar type 2 cells drives progressive pulmonary fibrosis
Rationale: Idiopathic pulmonary fibrosis (IPF) is an insidious and fatal interstitial lung
disease associated with declining pulmonary function. Accelerated aging, loss of epithelial …
disease associated with declining pulmonary function. Accelerated aging, loss of epithelial …
Collagen-producing lung cell atlas identifies multiple subsets with distinct localization and relevance to fibrosis
Collagen-producing cells maintain the complex architecture of the lung and drive pathologic
scarring in pulmonary fibrosis. Here we perform single-cell RNA-sequencing to identify all …
scarring in pulmonary fibrosis. Here we perform single-cell RNA-sequencing to identify all …
Interactions between hyaluronan and its receptors (CD44, RHAMM) regulate the activities of inflammation and cancer
S Misra, VC Hascall, RR Markwald… - Frontiers in …, 2015 - frontiersin.org
The glycosaminoglycan hyaluronan (HA), a major component of extracellular matrices, and
cell surface receptors of HA have been proposed to have pivotal roles in cell proliferation …
cell surface receptors of HA have been proposed to have pivotal roles in cell proliferation …