Nucleic acid aptamers are single-stranded DNA or RNA of 20–100 nucleotides in length that
have attracted substantial scientific interest due to their ability to specifically bind to target …

Endothelial cells (EC) respond to injury by releasing numerous factors, including von
Willebrand factor (VWF). High circulating levels of unusually large VWF multimers (UL …

Background: von Willebrand factor (VWF) has a role in both hemostasis and thrombosis.
Platelets adhere to damaged arteries by interactions between the VWF A1‐domain and …

Deficiency of a disintegrin and metalloproteinase with a thrombospondin type 1 motif,
member 13 (ADAMTS13), a VWF-cleaving protease, is the key factor in the pathogenesis of …

Thrombotic thrombocytopenic purpura (TTP) is the prototypical microangiopathy
characterized by disseminated microthromboses, hemolytic anemia, and ultimately organ …

The function of von Willebrand factor (VWF) is regulated by proteolysis, which limits its
multimeric size and ability to tether platelets. The importance of ADAMTS13 metalloprotease …

ADAMTS13 is a multidomain protease that limits platelet thrombogenesis through the
cleavage of von Willebrand factor (VWF). We previously identified 2 types of mouse …

Objective—Previous studies have demonstrated a role for plasmin in regulating plasma von
Willebrand factor (VWF) multimer composition. Moreover, emerging data have shown that …

Ultralarge von Willebrand factor (UL-VWF) multimers are thought to play a central role in
pathogenesis of the disease thrombotic thrombocytopenic purpura (TTP); however …

BACKGROUND Acquired thrombotic thrombocytopenia purpura (TTP) is a life‐threatening
illness caused by autoantibodies that decrease the activity of ADAMTS13, the von …