Auditory neuropathy—neural and synaptic mechanisms

T Moser, A Starr - Nature Reviews Neurology, 2016 - nature.com
Sensorineural hearing impairment is the most common form of hearing loss, and
encompasses pathologies of the cochlea and the auditory nerve. Hearing impairment …

Sensory processing at ribbon synapses in the retina and the cochlea

T Moser, CP Grabner, F Schmitz - Physiological reviews, 2020 - journals.physiology.org
In recent years, sensory neuroscientists have made major efforts to dissect the structure and
function of ribbon synapses which process sensory information in the eye and ear. This …

[HTML][HTML] Sensory neuron diversity in the inner ear is shaped by activity

BR Shrestha, C Chia, L Wu, SG Kujawa, MC Liberman… - Cell, 2018 - cell.com
In the auditory system, type I spiral ganglion neurons (SGNs) convey complex acoustic
information from inner hair cells (IHCs) to the brainstem. Although SGNs exhibit variation in …

[图书][B] Principles of neural design

P Sterling, S Laughlin - 2015 - books.google.com
Neuroscience research has exploded, with more than fifty thousand neuroscientists applying
increasingly advanced methods. A mountain of new facts and mechanisms has emerged …

Molecular signatures define subtypes of auditory afferents with distinct peripheral projection patterns and physiological properties

C Siebald, PFY Vincent, RT Bottom… - Proceedings of the …, 2023 - National Acad Sciences
Type I spiral ganglion neurons (SGNs) are the auditory afferents that transmit sound
information from cochlear inner hair cells (IHCs) to the brainstem. These afferents consist of …

Adding insult to injury: cochlear nerve degeneration after “temporary” noise-induced hearing loss

SG Kujawa, MC Liberman - Journal of Neuroscience, 2009 - Soc Neuroscience
Overexposure to intense sound can cause temporary or permanent hearing loss.
Postexposure recovery of threshold sensitivity has been assumed to indicate reversal of …

[HTML][HTML] Breaking the diffraction barrier: super-resolution imaging of cells

B Huang, H Babcock, X Zhuang - Cell, 2010 - cell.com
Anyone who has used a light microscope has wished that its resolution could be a little
better. Now, after centuries of gradual improvements, fluorescence microscopy has made a …

[HTML][HTML] Neuronal heterogeneity and stereotyped connectivity in the auditory afferent system

C Petitpré, H Wu, A Sharma, A Tokarska… - Nature …, 2018 - nature.com
Spiral ganglion (SG) neurons of the cochlea convey all auditory inputs to the brain, yet the
cellular and molecular complexity necessary to decode the various acoustic features in the …

Aging after noise exposure: acceleration of cochlear synaptopathy in “recovered” ears

KA Fernandez, PWC Jeffers, K Lall… - Journal of …, 2015 - Soc Neuroscience
Cochlear synaptic loss, rather than hair cell death, is the earliest sign of damage in both
noise-and age-related hearing impairment (;). Here, we compare cochlear aging after two …

[HTML][HTML] Superresolution imaging of chemical synapses in the brain

A Dani, B Huang, J Bergan, C Dulac, X Zhuang - Neuron, 2010 - cell.com
Determination of the molecular architecture of synapses requires nanoscopic image
resolution and specific molecular recognition, a task that has so far defied many …