T cell engineering has changed the landscape of cancer immunotherapy. Chimeric antigen
receptor T cells have demonstrated a remarkable efficacy in the treatment of B cell …

The T cell receptor (TCR) complex is a naturally occurring antigen sensor that detects,
amplifies and coordinates cellular immune responses to epitopes derived from cell surface …

T cell receptors (TCRs) enable T cells to specifically recognize mutations in cancer cells,–.
Here we developed a clinical-grade approach based on CRISPR–Cas9 non-viral precision …

Two types of engineered T cells have been successfully used to treat patients with cancer,
one with an antigen recognition domain derived from antibodies [chimeric antigen receptors …

CRISPR technology has transformed multiple fields, including cancer and immunology.
CRISPR‐based gene editing and screening empowers direct genomic manipulation of …

Advanced gene transfer technologies and profound immunological insights have enabled
substantial increases in the efficacy of anticancer adoptive cellular therapy (ACT). In recent …

Vigorous CD8+ T cells play a crucial role in recognizing tumor cells and combating solid
tumors. How T cells efficiently recognize and target tumor antigens, and how they maintain …

Adoptive regulatory T (Treg) cell therapy is predicted to modulate immune tolerance in
autoimmune diseases, including type 1 diabetes (T1D). However, the requirement for …

Designing effective antileukemic immunotherapy will require understanding mechanisms
underlying tumor control or resistance. Here, we report a mechanism of escape from …

To study and then harness the tumor-specific T cell dynamics after allogeneic hematopoietic
stem cell transplant, we typed the frequency, phenotype, and function of lymphocytes …