Patients with a diverse spectrum of rare genetic disorders can present with inflammatory
bowel disease (monogenic IBD). Patients with these disorders often develop symptoms …

In response to various immune challenges, females show better survival than males; the X
chromosome has an important role in this immunological advantage. X chromosome-linked …

An international panel of experts prepared an evidenced-based guideline for vaccination of
immunocompromised adults and children. These guidelines are intended for use by primary …

Very early onset inflammatory bowel disease (VEO-IBD) is defined as IBD presenting before
6 years of age. When compared with IBD diagnosed in older children, VEO-IBD has some …

The human newborn infant is susceptible to gut inflammatory disorders. In particular, growth-
restricted infants or infants born prematurely may develop a severe form of intestinal …

The American Academy of Allergy, Asthma & Immunology (AAAAI) and the American
College of Allergy, Asthma & Immunology (ACAAI) have jointly accepted responsibility for …

Autosomal recessive IRAK-4 and MyD88 deficiencies predispose affected patients to
recurrent invasive pyogenic bacterial infection. Both defects result in the selective …

The purpose of this Practice Parameter for the Diagnosis and Management of Primary
Immunodeficiency is to provide the consultant allergist/immunologist with a practical guide …

Mendelian susceptibility to mycobacterial diseases confers predisposition to clinical disease
caused by weakly virulent mycobacterial species in otherwise healthy individuals. Since …

BACKGROUND: Severe combined immunodeficiency (SCID) is a treatable, inherited lack of
cellular and humoral immunity caused by diverse mutations in several different genes and …