In all cells, proteins are continuously synthesized and degraded to maintain protein
homeostasis and modify gene expression levels in response to stimuli. Collectively, the …

To perform computations with the efficiency necessary for animal survival, neocortical
microcircuits must be capable of reconfiguring in response to experience, while carefully …

To form synaptic connections and store information, neurons continuously remodel their
proteomes. The impressive length of dendrites and axons imposes logistical challenges to …

Neuronal homeostasis prevents hyperactivity and hypoactivity. Age-related hyperactivity
suggests homeostasis may be dysregulated in later life. However, plasticity mechanisms …

The proteasome, the major protein-degradation machine in cells, regulates neuronal
synapses and long-term information storage. Here, using super-resolution microscopy, we …

Neurons continuously adapt to external cues and challenges, including stimulation, plasticity-
inducing signals and aging. These adaptations are critical for neuronal physiology and …

Neurons are characterized by a complex morphology that enables the generation of
subcellular compartments with unique biochemical and biophysical properties, such as …

Alzheimer's disease (AD) is the leading cause of dementia in aging individuals. Yet, the
pathophysiological processes involved in AD onset and progression are still poorly …

While it has long been known that protein synthesis is necessary for long-term memory in
the brain, the logistics of neuronal protein synthesis is complicated by the extensive …

Dendritic spines, the tiny and actin-rich protrusions emerging from dendrites, are the
subcellular locations of excitatory synapses in the mammalian brain that control synaptic …