Near infrared spectroscopy: A mature analytical technique with new perspectives–A review

C Pasquini - Analytica chimica acta, 2018 - Elsevier
Last decade's advances and modern aspects of near infrared spectroscopy are critically
examined and reviewed. Innovative instrumentation, highlighted by portable and imaging …

[HTML][HTML] Process analytical technologies–advances in bioprocess integration and future perspectives

G Gerzon, Y Sheng, M Kirkitadze - Journal of pharmaceutical and …, 2022 - Elsevier
Abstract Process Analytical Technology (PAT) instruments include analyzers capable of
measuring physical and chemical process parameters and key attributes with the goal of …

Assessment of recent process analytical technology (PAT) trends: a multiauthor review

LL Simon, H Pataki, G Marosi, F Meemken… - … Process Research & …, 2015 - ACS Publications
This multiauthor review article aims to bring readers up to date with some of the current
trends in the field of process analytical technology (PAT) by summarizing each aspect of the …

Towards smart biomanufacturing: a perspective on recent developments in industrial measurement and monitoring technologies for bio-based production processes

CL Gargalo, I Udugama, K Pontius… - Journal of Industrial …, 2020 - academic.oup.com
The biomanufacturing industry has now the opportunity to upgrade its production processes
to be in harmony with the latest industrial revolution. Technology creates capabilities that …

Sensor systems for bioprocess monitoring

P Biechele, C Busse, D Solle… - Engineering in Life …, 2015 - Wiley Online Library
The ability to measure all process variables is of great importance in the field of bioprocess
monitoring and control, and continuous, real‐time measurements are highly desired. The …

A review of control strategies for manipulating the feed rate in fed-batch fermentation processes

L Mears, SM Stocks, G Sin, KV Gernaey - Journal of biotechnology, 2017 - Elsevier
A majority of industrial fermentation processes are operated in fed-batch mode. In this case,
the rate of feed addition to the system is a focus for optimising the process operation, as it …

Real time monitoring of multiple parameters in mammalian cell culture bioreactors using an in‐line Raman spectroscopy probe

NR Abu‐Absi, BM Kenty, ME Cuellar… - Biotechnology and …, 2011 - Wiley Online Library
The FDA's process analytical technology initiative encourages drug manufacturers to apply
innovative ideas to better understand their processes. There are many challenges to …

A fuzzy optimization strategy for the implementation of RBF LSSVR model in vis–NIR analysis of pomelo maturity

H Chen, H Qiao, L Xu, Q Feng… - IEEE Transactions on …, 2019 - ieeexplore.ieee.org
Spectral analysis is a practical technology used for rapid analysis of fruit maturity. Least-
squares support vector regression (LSSVR) with radial basis function (RBF) kernel is an …

Applications of Raman spectroscopy in biopharmaceutical manufacturing: a short review

K Buckley, AG Ryder - Applied spectroscopy, 2017 - journals.sagepub.com
The production of active pharmaceutical ingredients (APIs) is currently undergoing its
biggest transformation in a century. The changes are based on the rapid and dramatic …

Spectroscopic sensors for in-line bioprocess monitoring in research and pharmaceutical industrial application

J Claßen, F Aupert, KF Reardon, D Solle… - Analytical and …, 2017 - Springer
The use of spectroscopic sensors for bioprocess monitoring is a powerful tool within the
process analytical technology (PAT) initiative of the US Food and Drug Administration …