Catalytic Aerobic Oxidation of C(sp3)−H Bonds

H Sterckx, B Morel, BUW Maes - … Chemie International Edition, 2019 - Wiley Online Library
Oxidation reactions are a key technology to transform hydrocarbons from petroleum
feedstock into chemicals of a higher oxidation state, allowing further chemical …

[HTML][HTML] Late-stage modification of bioactive compounds: Improving druggability through efficient molecular editing

T Huo, X Zhao, Z Cheng, J Wei, M Zhu, X Dou… - … Pharmaceutica Sinica B, 2024 - Elsevier
Synthetic chemistry plays an indispensable role in drug discovery, contributing to hit
compounds identification, lead compounds optimization, candidate drugs preparation, and …

Selective Aerobic Oxidation of Methylarenes to Benzaldehydes Catalyzed by N‐Hydroxyphthalimide and Cobalt(II) Acetate in Hexafluoropropan‐2‐ol

E Gaster, S Kozuch, D Pappo - … Chemie International Edition, 2017 - Wiley Online Library
Efficient and highly selective catalytic conditions for the aerobic autoxidation of
methylarenes to benzaldehydes, based on N‐hydroxyphthalimide (NHPI) and cobalt (II) …

Co/NHPI-mediated aerobic oxygenation of benzylic C–H bonds in pharmaceutically relevant molecules

DP Hruszkewycz, KC Miles, OR Thiel, SS Stahl - Chemical science, 2017 - pubs.rsc.org
A simple cobalt (II)/N-hydroxyphthalimide catalyst system has been identified for selective
conversion of benzylic methylene groups in pharmaceutically relevant (hetero) arenes to the …

A gC 3 N 4-based heterogeneous photocatalyst for visible light mediated aerobic benzylic C–H oxygenations

P Geng, Y Tang, G Pan, W Wang, J Hu, Y Cai - Green Chemistry, 2019 - pubs.rsc.org
A metal-free heterogeneous photocatalytic system has been developed for highly efficient
benzylic C–H oxygenations using oxygen as an oxidant. This visible light mediated …

Electrochemical benzylic oxidation of C–H bonds

JA Marko, A Durgham, SL Bretz, W Liu - Chemical Communications, 2019 - pubs.rsc.org
Oxidized products have become increasingly valuable as building blocks for a wide variety
of different processes and fine chemistry, especially in the benzylic position. We report …

Regioselective synthesis of 4-functionalized pyridines

C Li, Z Yan, B Wang, J Li, W Lyu, Z Wang, N Jiao… - Chem, 2024 - cell.com
Functionalized pyridines are privileged scaffolds in various fields. The C-4 selective
functionalization of pyridines is perhaps the most convenient protocol to pyridine derivatives …

Recent trends in catalytic sp 3 C–H functionalization of heterocycles

M Kaur, JF Van Humbeck - Organic & Biomolecular Chemistry, 2020 - pubs.rsc.org
Heterocycles are a ubiquitous substructure in organic small molecules designed for use in
materials and medicines. Recent work in catalysis has focused on enabling access to new …

Visible‐Light‐Induced Oxidation of Diazenyl‐Protected Tetrahydroisoquinolines and Isoindolines for the Synthesis of Functionalized Lactams

T Zhang, Y Wang, B Wang, W Jin, Y Xia… - Advanced Synthesis …, 2022 - Wiley Online Library
A visible‐light‐induced oxidation of diazenyl‐protected tetrahydroisoquinolines and
isoindolines for the synthesis of structurally diverse lactams is developed. The reaction was …

The effect of dissolved oxygen on kinetics during continuous biocatalytic oxidations

RM Lindeque, JM Woodley - Organic Process Research & …, 2020 - ACS Publications
Conventional oxidation catalysts frequently exhibit limited selectivity, restricting their use in
industrial syntheses. In particular, for the continuous synthesis of complex active …