Gene drives may be capable of addressing ecological problems by altering entire
populations of wild organisms, but their use has remained largely theoretical due to …

Engineered gene drives—the process of stimulating the biased inheritance of specific genes—
have the potential to enable the spread of desirable genes throughout wild populations or to …

Human pathogens that are transmitted by insects are a global problem, particularly those
vectored by mosquitoes; for example, malaria parasites transmitted by Anopheles species …

Nucleic acids have attracted widespread attention due to the simplicity with which they can
be designed to form discrete structures and programmed to perform specific functions at the …

A functioning gene drive system could fundamentally change our strategies for the control of
vector-borne diseases by facilitating rapid dissemination of transgenes that prevent …

Gene drive systems promote the spread of genetic elements through populations by
assuring they are inherited more often than Mendelian segregation would predict (see the …

Existing transgenic RNAi resources in Drosophila melanogaster based on long double-
stranded hairpin RNAs are powerful tools for functional studies, but they are ineffective in …

CRISPR/Cas9 gene drive (CGD) promises to be a highly adaptable approach for spreading
genetically engineered alleles throughout a species, even if those alleles impair …

Genetic strategies that reduce or block pathogen transmission by mosquitoes have been
proposed as a means of augmenting current control measures to reduce the growing burden …

Meiotic drivers are genetic variants that selfishly manipulate the production of gametes to
increase their own rate of transmission, often to the detriment of the rest of the genome and …