New insight into circRNAs: characterization, strategies, and biomedical applications

XY Feng, SX Zhu, KJ Pu, HJ Huang, YQ Chen… - … Hematology & Oncology, 2023 - Springer
Circular RNAs (circRNAs) are a class of covalently closed, endogenous ncRNAs. Most
circRNAs are derived from exonic or intronic sequences by precursor RNA back-splicing …

Insights into the role of CircRNAs: biogenesis, characterization, functional, and clinical impact in human malignancies

S Nisar, AA Bhat, M Singh, T Karedath… - Frontiers in cell and …, 2021 - frontiersin.org
Circular RNAs (circRNAs) are an evolutionarily conserved novel class of non-coding
endogenous RNAs (ncRNAs) found in the eukaryotic transcriptome, originally believed to be …

isoCirc catalogs full-length circular RNA isoforms in human transcriptomes

R Xin, Y Gao, Y Gao, R Wang… - Nature …, 2021 - nature.com
Circular RNAs (circRNAs) have emerged as an important class of functional RNA molecules.
Short-read RNA sequencing (RNA-seq) is a widely used strategy to identify circRNAs …

Current advances in circular RNA detection and investigation methods: Are we running in circles?

R Drula, C Braicu… - Wiley Interdisciplinary …, 2024 - Wiley Online Library
Circular RNAs (circRNAs), characterized by their closed‐loop structure, have emerged as
significant transcriptomic regulators, with roles spanning from microRNA sponging to …

[HTML][HTML] Circular RNAs in glioma: molecular functions and pathological implications

C Tang, X He, L Jia, X Zhang - Non-coding RNA research, 2024 - Elsevier
Circular RNAs (circRNAs) are a special class of non-coding RNAs with the ring structure.
They are stable, abundant and conservative across mammals. The biogenesis and …

Comprehensive landscape and future perspectives of circular RNAs in colorectal cancer

F Long, Z Lin, L Li, M Ma, Z Lu, L Jing, X Li, C Lin - Molecular cancer, 2021 - Springer
Colorectal cancer (CRC) is a common hereditary tumor that is often fatal. Its pathogenesis
involves multiple genes, including circular RNAs (circRNAs). Notably, circRNAs constitute a …

Biogenesis, functions, interactions, and resources of non-coding RNAs in plants

H Chao, Y Hu, L Zhao, S Xin, Q Ni, P Zhang… - International Journal of …, 2022 - mdpi.com
Plant transcriptomes encompass a large number of functional non-coding RNAs (ncRNAs),
only some of which have protein-coding capacity. Since their initial discovery, ncRNAs have …

The recent advancements in circRNA research: From biogenesis to therapeutic interventions

A Malviya, R Bhuyan - Pathology-Research and Practice, 2023 - Elsevier
Circular RNAs (circRNAs) belong to the genre of long non-coding RNAs that are formed by
special back-splicing events and are currently the molecule of interest for studies globally …

RNA-seq data science: From raw data to effective interpretation

D Deshpande, K Chhugani, Y Chang… - Frontiers in …, 2023 - frontiersin.org
RNA sequencing (RNA-seq) has become an exemplary technology in modern biology and
clinical science. Its immense popularity is due in large part to the continuous efforts of the …

Circular RNA hsa_circ_0007364 increases cervical cancer progression through activating methionine adenosyltransferase II alpha (MAT2A) expression by restraining …

H Chen, B Gu, X Zhao, Y Zhao, S Huo, X Liu, H Lu - Bioengineered, 2020 - Taylor & Francis
Emerging evidence suggested that circular RNAs (circRNAs) play critical roles in cervical
cancer (CC) progression. However, the roles and molecular mechanisms of …