In addition to the canonical right-handed double helix, other DNA structures, termed 'non-B
DNA', can form in the genomes across the tree of life. Non-B DNA regulates multiple cellular …

Abstract G-quadruplex (G4) is a four-stranded helical DNA secondary structure formed by
guanine-rich sequence folding, and G4 has been computationally predicted to exist in a …

Abstract miRNAs are a class of small non-coding RNA molecules that play important roles in
gene regulation. They are crucial for maintaining normal cellular functions, and …

Abstract G-quadruplexes (G4s) are non-canonical four-stranded structures and are
emerging as novel genetic regulatory elements. However, a comprehensive genomic …

Abstract G-quadruplexes (G4s) are non-canonical nucleic acids secondary structures that
involve in the regulation of some key biological processes, such as replication, transcription …

Plant viruses seriously disrupt crop growth and development, and classic protein-targeted
antiviral drugs could not provide complete protection against them. It is urgent to develop …

African Swine Fever Virus (ASFV), a lethal hemorrhagic fever of the swine, poses a major
threat to the world's swine population and has so far resulted in devastating socio-economic …

G-quadruplex DNA structures exhibit a profound influence on essential biological
processes, including transcription, replication, telomere maintenance, and genomic stability …

Thèse présentée à la Faculté de médecine et des sciences de la santé en vue de l'obtention
du diplôme de philosophiae doctor (Ph. D.) en Biochimie, Faculté de médecine et des …