An endophenotype is a heritable trait that is generally considered to be more highly,
associated with a gene-based neurological deficit than a disease phenotype itself. Such …

Synapse loss and synaptic dysfunction are pathological processes already involved in the
early stages of Alzheimer's disease (AD). Synapses consist principally of neuronal …

Background Nutrition is an important modifiable risk factor in Alzheimer's disease. Previous
trials of the multinutrient Fortasyn Connect showed benefits in mild Alzheimer's disease …

OBJECTIVE: To investigate the effect of a medical food on cognitive function in people with
mild Alzheimer's disease (AD). METHODS: A total of 225 drug-naïve AD patients …

Background Synaptic loss is a major hallmark of Alzheimer's disease (AD). Disturbed
organisation of large-scale functional brain networks in AD might reflect synaptic loss and …

Benefits on cognition from docosahexaenoic acid (DHA, 22: 6 n‐3) intake are absent in
humans carrying apolipoprotein E ε4 allele (APOE 4), the most important genetic risk factor …

New brain synapses form when a postsynaptic structure, the dendritic spine, interacts with a
presynaptic terminal. Brain synapses and dendritic spines, membrane-rich structures, are …

Alzheimer's disease (AD) is a heterogeneous and devastating neurodegenerative disease
with increasing socioeconomic burden for society. In the past 30 y, notwithstanding …

Abstract Cholesterol, omega-3 fatty acids, and triglycerides have been postulated to play
roles in affecting cognition in Alzheimer's disease (AD), the elderly, and obesity. Animal …

Brain neurons form synapses throughout the life span. This process is initiated by neuronal
depolarization, however the numbers of synapses thus formed depend on brain levels of …