The emerging nature of astrocyte diversity

BS Khakh, B Deneen - Annual review of neuroscience, 2019 - annualreviews.org
Astrocytes are morphologically complex, ubiquitous cells that are viewed as a
homogeneous population tiling the entire central nervous system (CNS). However, this view …

[HTML][HTML] Cell biology of astrocyte-synapse interactions

NJ Allen, C Eroglu - Neuron, 2017 - cell.com
Astrocytes, the most abundant glial cells in the mammalian brain, are critical regulators of
brain development and physiology through dynamic and often bidirectional interactions with …

Interleukin-33 in tissue homeostasis, injury, and inflammation

AB Molofsky, AK Savage, RM Locksley - Immunity, 2015 - cell.com
Interleukin-33 (IL-33) is a nuclear-associated cytokine of the IL-1 family originally described
as a potent inducer of allergic type 2 immunity. IL-33 signals via the receptor ST2, which is …

New transgenic mouse lines for selectively targeting astrocytes and studying calcium signals in astrocyte processes in situ and in vivo

R Srinivasan, TY Lu, H Chai, J Xu, BS Huang… - Neuron, 2016 - cell.com
Astrocytes exist throughout the nervous system and are proposed to affect neural circuits
and behavior. However, studying astrocytes has proven difficult because of the lack of tools …

SOX9 is an astrocyte-specific nuclear marker in the adult brain outside the neurogenic regions

W Sun, A Cornwell, J Li, S Peng, MJ Osorio… - Journal of …, 2017 - Soc Neuroscience
Astrocytes have in recent years become the focus of intense experimental interest, yet
markers for their definitive identification remain both scarce and imperfect. Astrocytes may …

Astrocyte heterogeneity in the adult central nervous system

SJ Miller - Frontiers in cellular neuroscience, 2018 - frontiersin.org
Astrocytes are the most abundant cell type in the central nervous system (CNS), providing
critical roles in the overall maintenance and homeostasis. Over 100 years ago, Cajal first …

Astrocyte development: a guide for the perplexed

AV Molofsky, B Deneen - Glia, 2015 - Wiley Online Library
Astrocytes are the predominant cell type in the brain and perform key functions vital to CNS
physiology, including blood brain barrier formation and maintenance, synaptogenesis …

Astrocyte-encoded positional cues maintain sensorimotor circuit integrity

AV Molofsky, KW Kelley, HH Tsai, SA Redmond… - Nature, 2014 - nature.com
Astrocytes, the most abundant cells in the central nervous system, promote synapse
formation and help to refine neural connectivity. Although they are allocated to spatially …

Variation among intact tissue samples reveals the core transcriptional features of human CNS cell classes

KW Kelley, H Nakao-Inoue, AV Molofsky… - Nature …, 2018 - nature.com
It is widely assumed that cells must be physically isolated to study their molecular profiles.
However, intact tissue samples naturally exhibit variation in cellular composition, which …

[HTML][HTML] Astrocyte endfoot formation controls the termination of oligodendrocyte precursor cell perivascular migration during development

Y Su, X Wang, Y Yang, L Chen, W Xia, KK Hoi, H Li… - Neuron, 2023 - cell.com
Oligodendrocyte precursor cells (OPCs) undergo an extensive and coordinated migration in
the developing CNS, using the pre-formed scaffold of developed blood vessels as their …