The emerging nature of astrocyte diversity
BS Khakh, B Deneen - Annual review of neuroscience, 2019 - annualreviews.org
Astrocytes are morphologically complex, ubiquitous cells that are viewed as a
homogeneous population tiling the entire central nervous system (CNS). However, this view …
homogeneous population tiling the entire central nervous system (CNS). However, this view …
[HTML][HTML] Cell biology of astrocyte-synapse interactions
Astrocytes, the most abundant glial cells in the mammalian brain, are critical regulators of
brain development and physiology through dynamic and often bidirectional interactions with …
brain development and physiology through dynamic and often bidirectional interactions with …
Interleukin-33 in tissue homeostasis, injury, and inflammation
AB Molofsky, AK Savage, RM Locksley - Immunity, 2015 - cell.com
Interleukin-33 (IL-33) is a nuclear-associated cytokine of the IL-1 family originally described
as a potent inducer of allergic type 2 immunity. IL-33 signals via the receptor ST2, which is …
as a potent inducer of allergic type 2 immunity. IL-33 signals via the receptor ST2, which is …
New transgenic mouse lines for selectively targeting astrocytes and studying calcium signals in astrocyte processes in situ and in vivo
Astrocytes exist throughout the nervous system and are proposed to affect neural circuits
and behavior. However, studying astrocytes has proven difficult because of the lack of tools …
and behavior. However, studying astrocytes has proven difficult because of the lack of tools …
SOX9 is an astrocyte-specific nuclear marker in the adult brain outside the neurogenic regions
Astrocytes have in recent years become the focus of intense experimental interest, yet
markers for their definitive identification remain both scarce and imperfect. Astrocytes may …
markers for their definitive identification remain both scarce and imperfect. Astrocytes may …
Astrocyte heterogeneity in the adult central nervous system
SJ Miller - Frontiers in cellular neuroscience, 2018 - frontiersin.org
Astrocytes are the most abundant cell type in the central nervous system (CNS), providing
critical roles in the overall maintenance and homeostasis. Over 100 years ago, Cajal first …
critical roles in the overall maintenance and homeostasis. Over 100 years ago, Cajal first …
Astrocyte development: a guide for the perplexed
AV Molofsky, B Deneen - Glia, 2015 - Wiley Online Library
Astrocytes are the predominant cell type in the brain and perform key functions vital to CNS
physiology, including blood brain barrier formation and maintenance, synaptogenesis …
physiology, including blood brain barrier formation and maintenance, synaptogenesis …
Astrocyte-encoded positional cues maintain sensorimotor circuit integrity
AV Molofsky, KW Kelley, HH Tsai, SA Redmond… - Nature, 2014 - nature.com
Astrocytes, the most abundant cells in the central nervous system, promote synapse
formation and help to refine neural connectivity. Although they are allocated to spatially …
formation and help to refine neural connectivity. Although they are allocated to spatially …
Variation among intact tissue samples reveals the core transcriptional features of human CNS cell classes
KW Kelley, H Nakao-Inoue, AV Molofsky… - Nature …, 2018 - nature.com
It is widely assumed that cells must be physically isolated to study their molecular profiles.
However, intact tissue samples naturally exhibit variation in cellular composition, which …
However, intact tissue samples naturally exhibit variation in cellular composition, which …
[HTML][HTML] Astrocyte endfoot formation controls the termination of oligodendrocyte precursor cell perivascular migration during development
Oligodendrocyte precursor cells (OPCs) undergo an extensive and coordinated migration in
the developing CNS, using the pre-formed scaffold of developed blood vessels as their …
the developing CNS, using the pre-formed scaffold of developed blood vessels as their …