Introduction The sarcomatoid morphology of muscle-invasive bladder cancer (MIBC) is
associated with unfavorable prognosis. However, the genomic, transcriptomic, and …

Drug sensitivity has always been at the core of individualized cancer chemotherapy.
However, we have been overwhelmed by large-scale pharmacogenomic data in the era of …

Background: DNA methylation played essential roles in regulating gene expression. The
impact of DNA methylation status on the occurrence and development of cancers has been …

Breast cancer susceptibility gene 1 (BRCA1) has been implicated in modulating metabolism
via transcriptional regulation. However, direct metabolic targets of BRCA 1 and the …

Abstract TP53 mutations (TP53mut) in AML patients associate with poor prognosis that may
affect therapy and outcome. In addition to TP53 mut patients, TCGA AML patient sequencing …

Abstract Background Inhibition of Hsp90 is desirable due to potential downregulation of
oncogenic clients. Early generation inhibitors bind to the N-terminal domain (NTD) but C …

Prostate cancer is one of the most common malignancies in men. Calcium signaling is
implicated in the progression of prostate cancer and plays a critical role in immune cell …

Background and objectives The computational prediction of drug responses based on the
analysis of multiple clinical features of the tumor will be a novel strategy for accomplishing …

NCI‐60 growth inhibition and gene expression profiles were analyzed using Pearson
correlation and functional enrichment computational tools to demonstrate critical …

Stomach adenocarcinoma (STAD) is one of the most common malignant digestive tumors.
Metabolic reprogramming is an essential feature of tumorigenesis. The roles of metabolic …