Highlights•Salivary genes are highly divergent and evolve under strong selective
pressure.•Gene duplication played a major role in evolution of novel salivary …

American Trypanosomiasis is an important neglected reemerging tropical parasitism,
infecting about 8 million people worldwide. Its agent, Trypanosoma cruzi, exhibits multiple …

Calreticulin from parasites and its vertebrate hosts share~ 50% identity and many of its
functions are equally conserved. However, the existing amino acid differences can affect its …

Because of its capacity to increase a physiologic inflammatory response, to stimulate
phagocytosis, to promote cell lysis and to enhance pathogen immunogenicity, the …

Chagas' disease is a zoonotic parasitic ailment now affecting more than 6 million people,
mainly in Latin America. Its agent, the protozoan Trypanosoma cruzi, is primarily transmitted …

Triatomines are blood-feeding insects that prey on vertebrate hosts. Their saliva is largely
responsible for their feeding success. The triatomine salivary content has been studied over …

To successfully infect, Trypanosoma cruzi evades and modulates the host immune
response. T. cruzi calreticulin (TcCalr) is a multifunctional, endoplasmic reticulum (ER) …

American Trypanosomiasis, a parasitic disease produced by Trypanosoma cruzi (T. cruzi),
endemic in Latin America, infects about 6 million people. During the chronic stage of the …

Microbes have developed mechanisms to resist the host immune defenses and some elicit
antitumor immune responses. About 6 million people are infected with Trypanosoma cruzi …

In arthropods, hematophagy has arisen several times throughout evolution. This specialized
feeding behavior offered a highly nutritious diet obtained during blood feeds. On the other …