Osteoporosis is a global public health problem, with fractures contributing to significant
morbidity and mortality. Although postmenopausal osteoporosis is most common, up to 30 …

Abstract Purpose of Review To summarize the evidence from recent studies on the shared
genetics between bone and muscle in humans. Recent Findings Genome-wide association …

Pediatric spina bifida (SB) and spinal cord injury (SCI) are unfortunately common in our
society, and their unique findings and comorbidities warrant special consideration. This …

Osteogenesis imperfecta (OI) is mainly characterized by bone fragility but muscle
abnormalities have been reported both in OI mouse models and in children with OI. Muscle …

Purpose Here, we review the skeletal effects of pediatric muscle disorders as well as muscle
impairment in pediatric bone disorders. Recent Findings When starting in utero, muscle …

Due to advancements in medical care, people with spina bifida (SB) are surviving well into
adulthood, resulting in a growing number of patients transitioning to an adult sector …

RESULTS: Bone fragility occurs early in the life of patients with SB as a result of a
disturbance that determines changes in bone shape, quantity, and quality, as poor …

Context Spina bifida (SB) can lead to changes in body composition and bone mineral
density (BMD) through diminished ambulation, renal impairment, and anticonvulsant …

Pathological fractures (PFs) are common in patients with spina bifida. However, most
previous studies refer to the overall fracture rate and largely neglecting putative age …

Fractures are a common comorbidity in children with the neural tube defect (NTD) spina
bifida. Mutations in the Wnt/planar cell polarity (PCP) pathway contribute to NTDs in humans …