Glucose is a key fuel and an important metabolic substrate in mammals. Renal proximal
tubular cells (PTCs) not only reabsorb filtered glucose but are also believed to play a role in …

Cytochrome P450s metabolize arachidonic acid to hydroxyeicosatetraenoic acids and
epoxyeicosatrienoic acids. These eicosanoids are formed in a tissue and cell-specific …

Regenerative medicine represents a critical clinical goal for patients with ESRD, but the
identification of renal adult multipotent progenitor cells has remained elusive. It is …

Although renin, the rate-limiting enzyme of the renin-angiotensin system (RAS), was first
discovered by Robert Tigerstedt and Bergman more than a century ago, the research on the …

High glucose inhibits renal proximal tubule cell proliferation and involves PKC, oxidative
stress, and TGF-β1. Background The alteration of renal cell growth is one of the early …

The properties of 20-hydroxyeicosatetraenoic acid and epoxyeicosatrienoic acids,
vasoactivity and modulation of ion transport and mediation/modulation of the effects of …

The electrogenic sodium/bicarbonate cotransporter 1 (NBCe1) on the basolateral side of the
renal proximal tubule plays a pivotal role in systemic acid-base homeostasis. Mutations in …

We measured soluble epoxide hydrolase (sEH) renal gene expression in prehypertensive (4
to 5 weeks old) spontaneously hypertensive rats of the Heidelberg SP substrain (SHR …

A novel eicosanoid, 5, 6-trans-epoxy-8Z, 11Z, 14Z-eicosatrienoic acid (5, 6-trans-EET), was
identified in rat red blood cells. Characterization of 5, 6-trans-EET in the sn-2 position of the …

Expression of a cytosolic cyan fluorescent fusion protein of angiotensin II (ECFP/ANG II) in
proximal tubules increases blood pressure in rodents. To determine cellular signaling …