Transforming growth factor (TGF)-β family members are multifunctional cytokines that elicit
their effects on cells, including endothelial and mural cells, via specific type I and type II …

Studies over the last decade have provided exciting new insights into potential mechanisms
underlying the pathogenesis of preeclampsia. The initiating event in preeclampsia is …

Purpose: Within heterogeneous tumors, subpopulations often labeled cancer stem cells
(CSC) have been identified that have enhanced tumorigenicity and chemoresistance in ex …

Genetic studies in mice and humans have revealed the pivotal role of transforming growth
factor-β (TGF-β) signaling during angiogenesis. Mice deficient for various TGF-β signaling …

Endoglin (CD105) is an accessory protein of the transforming growth factor-β receptor
system expressed on vascular endothelial cells. Mutation of the endoglin gene is associated …

Endoglin is a transmembrane auxillary receptor for transforming growth factor-β (TGF-β) that
is predominantly expressed on proliferating endothelial cells. Endoglin deficient mice die …

The transforming growth factor β (TGF-β) signaling pathway plays a key role in different
physiological processes such as development, cellular proliferation, extracellular matrix …

Biochemical studies in endothelial cells (ECs) and genetic studies in mice and humans have
yielded major insights into the role of transforming growth factor β (TGF-β) and its …

Endoglin (CD105) is an integral membrane glycoprotein that serves as a coreceptor for
members of the transforming growth factor-β superfamily of proteins. A major role for …

It is now apparent that regulation of blood vessel growth contributes to the classical actions
of hormones on development, growth, and reproduction. Endothelial cells are ideally …