PIWI-interacting RNAs (piRNAs) are a class of small non-coding RNAs that associate with
proteins of the PIWI clade of the Argonaute family. First identified in animal germ line cells …

Abstract PIWI-interacting RNAs (piRNAs), small noncoding RNAs 24–35 nucleotides long,
are essential for animal fertility. They play critical roles in a range of functions, including …

In eukaryotes, small RNA guides, such as small interfering RNAs and microRNAs, direct
AGO-clade Argonaute proteins to regulate gene expression and defend the genome against …

PIWI-interacting RNA (piRNA) pathways control transposable elements (TEs) and
endogenous genes, playing important roles in animal gamete formation. However, the …

In animals, PIWI-interacting RNAs (piRNAs) direct PIWI proteins to silence complementary
targets such as transposons. In Drosophila and other species with a maternally specified …

Argonaute proteins use nucleic acid guides to find and bind specific DNA or RNA target
sequences. Argonaute proteins have diverse biological functions and many retain their …

In animals, PIWI-interacting RNAs (piRNAs) silence transposons, fight viral infections, and
regulate gene expression. piRNA biogenesis concludes with 3′ terminal trimming and 2 …

PIWI proteins and their associated piRNAs act to silence transposons and promote
gametogenesis. Murine PIWI proteins MIWI, MILI, and MIWI2 have multiple arginine and …

Nonsense-mediated RNA decay (NMD) is a highly conserved and selective RNA turnover
pathway that depends on the endonuclease SMG6. Here, we show that SMG6 is essential …

ABSTRACT PIWI proteins and their associated PIWI-interacting RNAs (piRNAs) constitute a
small RNA-based adaptive immune system that restricts the deleterious activity of mobile …