[HTML][HTML] Targeting the orexin/hypocretin system for the treatment of neuropsychiatric and neurodegenerative diseases: From animal to clinical studies

M Ten-Blanco, Á Flores, L Cristino… - Frontiers in …, 2023 - Elsevier
Orexins (also known as hypocretins) are neuropeptides located exclusively in hypothalamic
neurons that have extensive projections throughout the central nervous system and bind two …

Sleep and eating disorders

KC Allison, A Spaeth, CM Hopkins - Current psychiatry reports, 2016 - Springer
Insomnia is related to an increased risk of eating disorders, while eating disorders are
related to more disrupted sleep. Insomnia is also linked to poorer treatment outcomes for …

Neuroendocrinology of reward in anorexia nervosa and bulimia nervosa: beyond leptin and ghrelin

LA Berner, TA Brown, JM Lavender, E Lopez… - Molecular and cellular …, 2019 - Elsevier
The pathophysiology of anorexia nervosa (AN) and bulimia nervosa (BN) are still poorly
understood, but psychobiological models have proposed a key role for disturbances in the …

Sleep, orexin and cognition

B Toor, LB Ray, A Pozzobon, SM Fogel - The Orexin System. Basic …, 2021 - karger.com
Orexins regulate a wide variety of biological functions, most notably the sleep-wake cycle,
reward and stress processing, alertness, vigilance, and cognitive functioning. Alterations of …

Other Specified Feeding or Eating Disorders (OSFED): Clinical heterogeneity and cognitive-behavioral therapy outcome

N Riesco, Z Agüera, R Granero… - European …, 2018 - cambridge.org
Background: with the DSM-5 new eating disorders (EDs) diagnostic subtypes were identified
within the Other Specified Feeding or Eating Disorders (OSFED) category, which have so far …

Sleep and eating disorders: current research and future directions

AR Cooper, KL Loeb, EL McGlinchey - Current Opinion in Psychology, 2020 - Elsevier
Highlights•The majority of individuals with eating disorders (EDs) report disturbed sleep, yet
there remains a dearth of research in this area.•Treating sleep throughout ED treatments …

Short‐term treatment outcomes and dropout risk in men and women with eating disorders

Z Agüera, I Sánchez, R Granero… - European Eating …, 2017 - Wiley Online Library
This study compared treatment outcomes between men and women with eating disorders
(EDs) and analysed clinical predictors of treatment outcome. Our sample consisted of 131 …

The case for investigating a bidirectional association between insomnia symptoms and eating disorder pathology

KA Christensen, NA Short - International Journal of Eating …, 2021 - Wiley Online Library
Many people with eating disorders (EDs) report symptoms of insomnia (ie, frequent difficulty
falling asleep, staying asleep, and/or early morning wakening) and sleep problems have …

Orexin/hypocretin and dysregulated eating: Promotion of foraging behavior

JR Barson - Brain research, 2020 - Elsevier
At its discovery, orexin/hypocretin (OX) was hypothesized to promote food intake.
Subsequently, with the identification of the participation of OX in numerous other …

The role of food addiction and lifetime substance use on eating disorder treatment outcomes

R Miranda-Olivos, Z Agüera, R Granero… - Nutrients, 2023 - mdpi.com
Food addiction (FA) and substance use (SU) in eating disorders (ED) have been associated
with a more dysfunctional clinical and psychopathological profile. However, their impact on …