[HTML][HTML] Targeting the orexin/hypocretin system for the treatment of neuropsychiatric and neurodegenerative diseases: From animal to clinical studies
Orexins (also known as hypocretins) are neuropeptides located exclusively in hypothalamic
neurons that have extensive projections throughout the central nervous system and bind two …
neurons that have extensive projections throughout the central nervous system and bind two …
Sleep and eating disorders
Insomnia is related to an increased risk of eating disorders, while eating disorders are
related to more disrupted sleep. Insomnia is also linked to poorer treatment outcomes for …
related to more disrupted sleep. Insomnia is also linked to poorer treatment outcomes for …
Neuroendocrinology of reward in anorexia nervosa and bulimia nervosa: beyond leptin and ghrelin
The pathophysiology of anorexia nervosa (AN) and bulimia nervosa (BN) are still poorly
understood, but psychobiological models have proposed a key role for disturbances in the …
understood, but psychobiological models have proposed a key role for disturbances in the …
Sleep, orexin and cognition
Orexins regulate a wide variety of biological functions, most notably the sleep-wake cycle,
reward and stress processing, alertness, vigilance, and cognitive functioning. Alterations of …
reward and stress processing, alertness, vigilance, and cognitive functioning. Alterations of …
Other Specified Feeding or Eating Disorders (OSFED): Clinical heterogeneity and cognitive-behavioral therapy outcome
Background: with the DSM-5 new eating disorders (EDs) diagnostic subtypes were identified
within the Other Specified Feeding or Eating Disorders (OSFED) category, which have so far …
within the Other Specified Feeding or Eating Disorders (OSFED) category, which have so far …
Sleep and eating disorders: current research and future directions
AR Cooper, KL Loeb, EL McGlinchey - Current Opinion in Psychology, 2020 - Elsevier
Highlights•The majority of individuals with eating disorders (EDs) report disturbed sleep, yet
there remains a dearth of research in this area.•Treating sleep throughout ED treatments …
there remains a dearth of research in this area.•Treating sleep throughout ED treatments …
Short‐term treatment outcomes and dropout risk in men and women with eating disorders
This study compared treatment outcomes between men and women with eating disorders
(EDs) and analysed clinical predictors of treatment outcome. Our sample consisted of 131 …
(EDs) and analysed clinical predictors of treatment outcome. Our sample consisted of 131 …
The case for investigating a bidirectional association between insomnia symptoms and eating disorder pathology
KA Christensen, NA Short - International Journal of Eating …, 2021 - Wiley Online Library
Many people with eating disorders (EDs) report symptoms of insomnia (ie, frequent difficulty
falling asleep, staying asleep, and/or early morning wakening) and sleep problems have …
falling asleep, staying asleep, and/or early morning wakening) and sleep problems have …
Orexin/hypocretin and dysregulated eating: Promotion of foraging behavior
JR Barson - Brain research, 2020 - Elsevier
At its discovery, orexin/hypocretin (OX) was hypothesized to promote food intake.
Subsequently, with the identification of the participation of OX in numerous other …
Subsequently, with the identification of the participation of OX in numerous other …
The role of food addiction and lifetime substance use on eating disorder treatment outcomes
Food addiction (FA) and substance use (SU) in eating disorders (ED) have been associated
with a more dysfunctional clinical and psychopathological profile. However, their impact on …
with a more dysfunctional clinical and psychopathological profile. However, their impact on …