Smart nanomaterials in cancer theranostics: challenges and opportunities

BK Kashyap, VV Singh, MK Solanki, A Kumar… - ACS …, 2023 - ACS Publications
Cancer is ranked as the second leading cause of death globally. Traditional cancer
therapies including chemotherapy are flawed, with off-target and on-target toxicities on the …

A review of nanotechnology-based approaches for breast cancer and triple-negative breast cancer

V Jain, H Kumar, HV Anod, P Chand, NV Gupta… - Journal of Controlled …, 2020 - Elsevier
Breast cancer (BC) is one of the most prevalent cancers in women. Triple-negative breast
cancer (TNBC) in which the three major receptors ie estrogen receptor (ER), progesterone …

Stem cell–homing hydrogel-based miR-29b-5p delivery promotes cartilage regeneration by suppressing senescence in an osteoarthritis rat model

J Zhu, S Yang, Y Qi, Z Gong, H Zhang, K Liang… - Science …, 2022 - science.org
Osteoarthritis (OA) is a common joint disease characterized by progressive loss of cartilage
and reduction in lubricating synovial fluid, which lacks effective treatments currently. Here …

Rolling circle replication for biosensing, bioimaging, and biomedicine

S Yue, Y Li, Z Qiao, W Song, S Bi - Trends in Biotechnology, 2021 - cell.com
Rolling circle replication (RCR), including rolling circle amplification (RCA) and rolling circle
transcription (RCT), is an isothermal enzymatic reaction. Because of its high amplification …

Smart nanovesicle-mediated immunogenic cell death through tumor microenvironment modulation for effective photodynamic immunotherapy

W Yang, F Zhang, H Deng, L Lin, S Wang, F Kang… - ACS …, 2019 - ACS Publications
Combination therapy that could better balance immune activation and suppressive signals
holds great potential in cancer immunotherapy. Herein, we serendipitously found that the pH …

DNA nanostructure-based nucleic acid probes: construction and biological applications

DX Wang, J Wang, YX Wang, YC Du, Y Huang… - Chemical …, 2021 - pubs.rsc.org
In recent years, DNA has been widely noted as a kind of material that can be used to
construct building blocks for biosensing, in vivo imaging, drug development, and disease …

[HTML][HTML] Drug resistance in metastatic breast cancer: tumor targeted nanomedicine to the rescue

V Gote, AR Nookala, PK Bolla, D Pal - International journal of molecular …, 2021 - mdpi.com
Breast cancer, specifically metastatic breast, is a leading cause of morbidity and mortality in
women. This is mainly due to relapse and reoccurrence of tumor. The primary reason for …

Functional DNA–polymer conjugates

CJ Whitfield, M Zhang, P Winterwerber, Y Wu… - Chemical …, 2021 - ACS Publications
DNA nanotechnology has seen large developments over the last 30 years through the
combination of solid phase synthesis and the discovery of DNA nanostructures. Solid phase …

Transformable ECM deprivation system effectively suppresses renal cell carcinoma by reversing anoikis resistance and increasing chemotherapy sensitivity

L Wang, C Li, J Wang, G Yang, Y Lv, B Fu… - Advanced …, 2022 - Wiley Online Library
Extracellular matrix (ECM) is crucial in various biological functions during tumor progression,
including induction of anoikis resistance and cell adhesion‐mediated drug resistance (CAM …

Hydrophobic interaction: a promising driving force for the biomedical applications of nucleic acids

F Xiao, Z Chen, Z Wei, L Tian - Advanced Science, 2020 - Wiley Online Library
The comprehensive understanding and proper use of supramolecular interactions have
become critical for the development of functional materials, and so is the biomedical …