The biophysics and cell biology of lipid droplets
Lipid droplets are intracellular organelles that are found in most cells, where they have
fundamental roles in metabolism. They function prominently in storing oil-based reserves of …
fundamental roles in metabolism. They function prominently in storing oil-based reserves of …
Epigenetics and human obesity
Background: Recent technological advances in epigenome profiling have led to an
increasing number of studies investigating the role of the epigenome in obesity. There is …
increasing number of studies investigating the role of the epigenome in obesity. There is …
Early experiences of threat, but not deprivation, are associated with accelerated biological aging in children and adolescents
Background Recent conceptual models argue that early life adversity (ELA) accelerates
development, which may contribute to poor mental and physical health outcomes. Evidence …
development, which may contribute to poor mental and physical health outcomes. Evidence …
Pan-cancer deconvolution of tumour composition using DNA methylation
The nature and extent of immune cell infiltration into solid tumours are key determinants of
therapeutic response. Here, using a DNA methylation-based approach to tumour cell …
therapeutic response. Here, using a DNA methylation-based approach to tumour cell …
A comparison of reference-based algorithms for correcting cell-type heterogeneity in Epigenome-Wide Association Studies
Background Intra-sample cellular heterogeneity presents numerous challenges to the
identification of biomarkers in large Epigenome-Wide Association Studies (EWAS). While a …
identification of biomarkers in large Epigenome-Wide Association Studies (EWAS). While a …
An integrated genetic-epigenetic analysis of schizophrenia: evidence for co-localization of genetic associations and differential DNA methylation
Background Schizophrenia is a highly heritable, neuropsychiatric disorder characterized by
episodic psychosis and altered cognitive function. Despite success in identifying genetic …
episodic psychosis and altered cognitive function. Despite success in identifying genetic …
Guidance for DNA methylation studies: statistical insights from the Illumina EPIC array
Background There has been a steady increase in the number of studies aiming to identify
DNA methylation differences associated with complex phenotypes. Many of the challenges …
DNA methylation differences associated with complex phenotypes. Many of the challenges …
Reference-free cell mixture adjustments in analysis of DNA methylation data
Motivation: Recently there has been increasing interest in the effects of cell mixture on the
measurement of DNA methylation, specifically the extent to which small perturbations in cell …
measurement of DNA methylation, specifically the extent to which small perturbations in cell …
DNA extracted from saliva for methylation studies of psychiatric traits: evidence tissue specificity and relatedness to brain
DNA methylation has become increasingly recognized in the etiology of psychiatric
disorders. Because brain tissue is not accessible in living humans, epigenetic studies are …
disorders. Because brain tissue is not accessible in living humans, epigenetic studies are …
Characterizing genetic and environmental influences on variable DNA methylation using monozygotic and dizygotic twins
Variation in DNA methylation is being increasingly associated with health and disease
outcomes. Although DNA methylation is hypothesized to be a mechanism by which both …
outcomes. Although DNA methylation is hypothesized to be a mechanism by which both …