During the past ten years, dramatic advances have been made in unraveling the biological
bases of age-related macular degeneration (AMD), the most common cause of irreversible …

Age-related macular degeneration (AMD) is a leading cause of irreversible blindness in the
world. Although the etiology and pathogenesis of AMD remain largely unclear, a complex …

In both atypical hemolytic uremic syndrome (aHUS) and C3 glomerulopathy (C3G)
complement plays a primary role in disease pathogenesis. Herein we report the outcome of …

Complement is the major humoral component of the innate immune system. It recognizes
pathogen-and damage-associated molecular patterns, and initiates the immune response in …

Background Studies of monogenic gastrointestinal diseases have revealed molecular
pathways critical to gut homeostasis and enabled the development of targeted therapies …

Atypical hemolytic uremic syndrome (aHUS) is a life-threatening thrombotic microangiopathy
that can progress, when untreated, to end-stage renal disease. Most frequently, aHUS is …

Dense Deposit Disease (DDD), or membranoproliferative glomerulonephritis type II, is a rare
renal disease characterized by dense deposits in the mesangium and along the glomerular …

The complement system is composed of more than 30 serum and membrane‐bound
proteins, all of which are needed for normal function of complement in innate and adaptive …

The atypical Hemolytic Uremic Syndrome (aHUS) is a rare thrombotic microangiopathy
leading to end stage renal disease in approximately 60% of patients. Over the last decade, a …

Complement is an essential part of innate immunity as it participates in host defense against
infections, disposal of cellular debris and apoptotic cells, inflammatory processes and …