Pathophysiology and probable etiology of cerebral small vessel disease in vascular dementia and Alzheimer's disease
Vascular cognitive impairment and dementia (VCID) is commonly caused by vascular
injuries in cerebral large and small vessels and is a key driver of age-related cognitive …
injuries in cerebral large and small vessels and is a key driver of age-related cognitive …
Emerging roles for CNS fibroblasts in health, injury and disease
CE Dorrier, HE Jones, L Pintarić… - Nature Reviews …, 2022 - nature.com
Recent transcriptomic, histological and functional studies have begun to shine light on the
fibroblasts present in the meninges, choroid plexus and perivascular spaces of the brain and …
fibroblasts present in the meninges, choroid plexus and perivascular spaces of the brain and …
Single-cell dissection of the human brain vasculature
Despite the importance of the cerebrovasculature in maintaining normal brain physiology
and in understanding neurodegeneration and drug delivery to the central nervous system …
and in understanding neurodegeneration and drug delivery to the central nervous system …
Molecular anatomy of adult mouse leptomeninges
R Pietilä, F Del Gaudio, L He, E Vázquez-Liébanas… - Neuron, 2023 - cell.com
Leptomeninges, consisting of the pia mater and arachnoid, form a connective tissue
investment and barrier enclosure of the brain. The exact nature of leptomeningeal cells has …
investment and barrier enclosure of the brain. The exact nature of leptomeningeal cells has …
The neurovasculome: key roles in brain health and cognitive impairment: a scientific statement from the American Heart Association/American Stroke Association
Background: Preservation of brain health has emerged as a leading public health priority for
the aging world population. Advances in neurovascular biology have revealed an intricate …
the aging world population. Advances in neurovascular biology have revealed an intricate …
Advances and controversies in meningeal biology
The dura, arachnoid and pia mater, as the constituent layers of the meninges, along with
cerebrospinal fluid in the subarachnoid space and ventricles, are essential protectors of the …
cerebrospinal fluid in the subarachnoid space and ventricles, are essential protectors of the …
Living on the edge of the CNS: meninges cell diversity in health and disease
The meninges are the fibrous covering of the central nervous system (CNS) which contain
vastly heterogeneous cell types within its three layers (dura, arachnoid, and pia). The dural …
vastly heterogeneous cell types within its three layers (dura, arachnoid, and pia). The dural …
Fibrotic scar in CNS injuries: from the cellular origins of fibroblasts to the molecular processes of fibrotic scar formation
Central nervous system (CNS) trauma activates a persistent repair response that leads to
fibrotic scar formation within the lesion. This scarring is similar to other organ fibrosis in …
fibrotic scar formation within the lesion. This scarring is similar to other organ fibrosis in …
[HTML][HTML] How does neurovascular unit dysfunction contribute to multiple sclerosis?
Multiple sclerosis is an inflammatory demyelinating disease of the central nervous system
(CNS) and the most common non-traumatic cause of neurological disability in young adults …
(CNS) and the most common non-traumatic cause of neurological disability in young adults …
Neuronal activity drives IGF2 expression from pericytes to form long-term memory
Investigations of memory mechanisms have been, thus far, neuron centric, despite the brain
comprising diverse cell types. Using rats and mice, we assessed the cell-type-specific …
comprising diverse cell types. Using rats and mice, we assessed the cell-type-specific …