SWI/SNF chromatin remodelling complexes use the energy of ATP hydrolysis to remodel
nucleosomes and to modulate transcription. Growing evidence indicates that these …

Macromolecular assemblies that regulate chromatin structure using the energy of ATP
hydrolysis have critical roles in development, cancer, and stem cell biology. The ATPases of …

The genetics of renal cancer is dominated by inactivation of the VHL tumour suppressor
gene in clear cell carcinoma (ccRCC), the commonest histological subtype. A recent large …

SWI/SNF is a multi-subunit chromatin remodeling complex that uses the energy of ATP
hydrolysis to reposition nucleosomes, thereby modulating gene expression. Accumulating …

Inactivation of the VHL tumor suppressor protein (pVHL) is a common event in clear cell
renal carcinoma, which is the most common form of kidney cancer. pVHL performs many …

Renal cell carcinoma of clear-cell type (ccRCC) is an enigmatic tumor type, characterized by
frequent inactivation of the VHL gene (infrequently mutated in other tumor types) …

Phosphatase and tensin homolog on chromosome ten (PTEN) is a tumor suppressor and an
antagonist of the phosphoinositide-3 kinase (PI3K) pathway. We identified a 576–amino …

PBRM1 is the second most commonly mutated gene after VHL in clear cell renal cell
carcinoma (ccRCC). However, the biological consequences of PBRM1 mutations for kidney …

The identification of mutations and deletions in the SMARCB1 locus in chromosome band
22q11. 2 in pediatric rhabdoid tumors provided the first evidence for the involvement of the …

Epigenetic alterations are associated with all aspects of cancer, from tumor initiation to
cancer progression and metastasis. It is now well understood that both losses and gains of …